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Hydroxyurea (Hydrea) is a medication with several important safety precautions and potential risks. It is crucial to be aware of these warnings and consult your healthcare provider with any concerns or symptoms you may experience.

• Bone Marrow Suppression: Hydroxyurea can reduce bone marrow function, leading to decreased levels of blood cells, including red cells, white cells, and platelets. This can result in anemia, increased susceptibility to infections, or easy bruising and bleeding. Regular blood tests will be conducted to monitor your blood cell counts. Notify your healthcare provider immediately if you experience persistent bleeding, blood in urine, pale or yellowish skin, weakness, fever, chills, sore throat, or any signs of infection.

• Cancer Risk: Long-term use of hydroxyurea might increase the risk of developing other cancers, such as leukemia and skin cancer. Protect your skin from sun exposure by using sunscreen and wearing protective clothing. Be vigilant for symptoms of cancer, including swollen glands, unexplained weight loss, night sweats, or unusual skin growths or moles, and report these to your doctor promptly.

• Pregnancy Risks: Hydroxyurea can harm an unborn baby. Women who can become pregnant should undergo a pregnancy test before starting treatment. Both males and females should use effective birth control during treatment and continue for at least six months after the last dose for females, and one year for males. Inform your healthcare provider immediately if pregnancy occurs during this period.

• Blood Vessel and Skin Issues: There have been reports of blood vessel damage and skin ulcers in individuals using hydroxyurea, particularly those who have taken interferon medications. Contact your provider if you notice any open sores on your body.

• Interactions with HIV Medications: Concurrent use of hydroxyurea with antiretroviral medications may lead to pancreas, liver, or nerve damage. Be alert for symptoms like stomach pain, nausea, vomiting, tingling in extremities, or yellowing of the skin or eyes, and inform your healthcare provider immediately.

• Radiation Therapy Reactions: If you have previously undergone radiation therapy, hydroxyurea may reactivate skin irritation in treated areas. Report any skin redness or discomfort to your provider.

• Lung Issues: There is a potential risk of lung damage and scarring (pulmonary fibrosis) in patients treated with hydroxyurea for blood cancers. Seek medical attention if you experience coughing or difficulty breathing.

In case of any unusual symptoms or overdose, contact your healthcare provider immediately for guidance and appropriate steps to take. Always follow your provider's instructions regarding dosage adjustments or discontinuation of the medication.

Common side effects:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Loss of appetite
• Mouth sores
• Headache
• Rashes
• Skin and nail changes
• Fatigue

Serious side effects:

• Significant changes in skin appearance
• Mental disturbances (confusion or hallucinations)
• Seizures
• Signs of liver or kidney issues (yellowing of the eyes or skin, changes in urine color)
• Symptoms of serious infections (repeated fevers, chills, cough, severe diarrhea)
• Serious bleeding problems
• Lung issues (chest pain or difficulty breathing)
• Allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Measles Virus Vaccine, Live
• Mumps Virus Vaccine, Live
• Rotavirus Vaccine, Live
• Rubella Virus Vaccine, Live
• Varicella Virus Vaccine, Live
• Zoster Vaccine, Live

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Didanosine
• Stavudine
• Adenovirus Vaccine
• Bacillus of Calmette and Guerin Vaccine, Live
• Cholera Vaccine, Live
• Dengue Tetravalent Vaccine, Live
• Influenza Virus Vaccine, Live
• Poliovirus Vaccine, Live
• Smallpox Vaccine
• Typhoid Vaccine, Live
• Yellow Fever Vaccine