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When using the Skyrizi pen, it's important to be aware of certain safety considerations to ensure proper administration and minimize potential risks.

Storage and Handling

• Refrigeration: Store the Skyrizi pen in the refrigerator at temperatures between 36°F to 46°F (2°C to 8°C). Keep it in its original carton to protect it from light until you're ready to use it.

• Room Temperature Preparation: Before injecting, remove the pen from the refrigerator and let it sit at room temperature, away from direct sunlight, for 30 to 90 minutes. Do not warm the pen using external heat sources like microwaves or hot water.

• Inspection Before Use: Before administering, check the liquid through the pen's inspection window. It should appear clear to yellow and may contain tiny white or clear particles. Do not use the pen if the liquid is discolored, cloudy, or contains flakes or large particles.

Injection Site Selection

• Appropriate Areas: Choose an injection site on the front of your thighs or your abdomen, ensuring it's at least 2 inches away from your navel.

• Avoid Certain Areas: Do not inject into skin that is sore, bruised, red, hard, scarred, has stretch marks, or areas affected by psoriasis.

Administration Precautions

• Cap Removal: Only remove the dark gray cap when you're ready to inject.

• Avoid Shaking: Do not shake the Skyrizi pen at any time.

• Single Use: Each Skyrizi pen is designed for one-time use. Do not reuse the pen.

Disposal

• Sharps Disposal: After use, dispose of the pen in an FDA-cleared sharps disposal container. Do not dispose of it in household trash unless permitted by local guidelines.

Additional Considerations

• Damaged Pens: Do not use the pen if it has been dropped, damaged, or if the carton perforations are broken. Return such products to the pharmacy.

• Frozen Product: Do not use the pen if the liquid has been frozen, even if it has been thawed.

By following these guidelines, you can help ensure the safe and effective use of the Skyrizi pen.

When using the Skyrizi pen, it's important to be aware of potential interactions with other medications and substances. Skyrizi (risankizumab) is a medication that modulates the immune system, and combining it with certain drugs can increase the risk of infections or other adverse effects.

One notable interaction is with upadacitinib, a medication used to treat rheumatoid arthritis and other conditions. Combining Skyrizi with upadacitinib may elevate the risk of serious and potentially fatal infections. In some cases, using medications that affect the immune system together can also increase the risk of developing certain types of cancer over time. It's crucial to inform your doctor if you're taking upadacitinib or any other medications that influence the immune system.

Additionally, Skyrizi can interact with live vaccines. Live vaccines contain weakened forms of viruses or bacteria and are designed to stimulate the immune system to build resistance against specific diseases. Since Skyrizi suppresses certain immune responses, receiving live vaccines during treatment can increase the risk of developing infections. Examples of live vaccines include those for measles, mumps, rubella (MMR), and chickenpox. Before starting Skyrizi, ensure that your vaccinations are up to date, and avoid live vaccines during treatment.

While there are no specific reports of Skyrizi interacting with alcohol, it's advisable to limit or avoid alcohol consumption during treatment. Alcohol can potentially worsen symptoms of conditions treated by Skyrizi, such as Crohn's disease and psoriasis.

Always inform your healthcare provider about all medications, supplements, and vaccines you are taking or plan to take. This information helps in assessing potential interactions and ensuring the safe and effective use of the Skyrizi pen.