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The following safety information outlines important warnings associated with the use of Sotyktu (deucravacitinib). It is crucial to understand these risks and consult your healthcare provider with any questions or concerns.

• Severe Allergic Reactions: Although rare, Sotyktu may trigger serious allergic reactions. Seek immediate medical attention if you experience facial or throat swelling, difficulty breathing, or a rash.

• Serious Infections: This medication may compromise your immune system, increasing your susceptibility to severe infections like tuberculosis, shingles, and hepatitis. You are at greater risk if you have existing or recurring infections, other health conditions that heighten infection risk, live in or travel to regions with high TB rates, or take other immune-suppressing medications.

• Muscle Damage: Sotyktu can lead to elevated creatine phosphokinase (CPK) levels, indicating potential muscle damage such as rhabdomyolysis. Notify your healthcare provider immediately if you experience unexplained muscle pain, tenderness, weakness, dark urine, fatigue, or fever, as treatment may need to be adjusted.

• Liver Damage: Elevated liver enzymes can occur with Sotyktu use, signaling possible liver damage. Regular liver function tests will be conducted to monitor your liver health. Report any symptoms like nausea, abdominal pain, or jaundice to your healthcare team promptly.

• Possible Risk of Cancer: Though extremely rare, some cancer cases, including lymphoma, liver, and breast cancer, have been reported in clinical studies. Discuss your medical history with your psoriasis specialist, especially if you've had cancer before or have concerns about cancer risk.

There are no specific contraindications listed for Sotyktu. Always discuss your medical history and any concerns with your healthcare provider to ensure this medication is suitable for you.

When taking this medication, you may experience some common side effects that are usually mild and manageable. These include upper respiratory infections, mouth ulcers, swollen hair follicles, and acne. Generally, these effects are not severe, but if they persist or worsen, it's advisable to consult with a healthcare provider.

There are more serious side effects that, although rare, require immediate medical attention. These include severe allergic reactions characterized by rash, difficulty breathing, dizziness, and swelling of the face or throat. Additionally, the drug can lower your immune response, making infections more severe or harder to heal, with symptoms such as persistent fever, chills, cough, or non-healing skin sores.

Severe muscle damage, known as rhabdomyolysis, is a potential risk, presenting as dark brown urine, extreme muscle pain, or weakness, accompanied by fever or tiredness. Liver damage is another critical concern, which can manifest through symptoms like persistent nausea, stomach pain, jaundice, or dark urine. Unexplained weight loss, unusual lumps, and signs of kidney problems, such as changes in urination, also warrant immediate medical consultation. In rare cases, this medication may increase the risk of cancer.

If you notice any other unusual effects, contact your healthcare provider for advice. Always remain vigilant and seek medical help promptly if you suspect any severe reactions.