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Sodium Polystyrene Sulfonate

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generic Sps (sodium Polystyrene Sulf)

Sodium polystyrene sulfonate, often known by its brand name Kayexalate, is a medication designed to manage high potassium levels in the blood, a condition known as hyperkalemia. This drug functions as a potassium binder, attaching to the potassium in the stomach and intestines to prevent its absorption. Consequently, the potassium is eliminated from the body through stool, effectively reducing blood potassium levels. Administered either orally or as an enema, sodium polystyrene sulfonate is available in liquid suspension or as a powder to be mixed. It's usually taken up to four times daily, but it's crucial to follow the dosage instructions provided by your healthcare provider. While effective, the medication may cause side effects such as nausea, vomiting, constipation, or diarrhea. Always consult with a healthcare professional before starting any new medication.
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15GM of 1, Sodium Polystyrene Sulfonate (1 Bottle)

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CVS

$19.65

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$2.00

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$4.41

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$5.46

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Sodium Polystyrene Sulfonate dosage forms

The average cost for 1 Bottle of Sodium Polystyrene Sulfonate (generic Sps (sodium Polystyrene Sulf)) at 15GM of 1 is $2 with a free coupon. This is 12.55% off the average retail price of $15.93
DosageQuantityPrice fromPer unit
15GM of 11 Bottle$2$2

Sodium Polystyrene Sulfonate Warnings

When using this medication, it is crucial to be aware of the following safety information and warnings. Consult your healthcare provider if you have any questions or concerns regarding these details.

  • Serious Gastrointestinal Risks: Although uncommon, sodium polystyrene sulfonate (SPS) may cause severe stomach and intestinal issues, such as bowel or intestinal necrosis. This condition results from insufficient blood flow to the intestines and can be life-threatening. The risk increases when SPS is taken alongside sorbitol, a sweetener and laxative. Avoid sorbitol while using SPS. Ensure normal bowel movements before taking this medication. Contact your healthcare provider immediately if you experience blood in your stool, nausea, vomiting, constipation, diarrhea, fever, or abdominal pain, as these may necessitate discontinuing the medication. Individuals with a history of intestinal problems, low blood volume, kidney issues, or those who are pregnant or have undergone intestinal surgery should exercise caution.

  • Electrolyte Imbalance: Sodium polystyrene sulfonate (SPS) can lead to reduced levels of potassium, magnesium, and calcium. Your healthcare provider may monitor these electrolytes during treatment. Inform them of all medications you are taking and consult them before starting any new ones, particularly those that may also lower electrolyte levels, such as loop diuretics. If you experience vomiting, diarrhea, or a loss of appetite, contact your provider, as your dosage may need adjustment. Watch for symptoms like muscle cramps, numbness, nausea, weakness, shortness of breath, or confusion, and report these to your healthcare provider as they may indicate low electrolyte levels.

  • Swelling: This medication contains salt, which can lead to fluid retention and swelling in the arms, legs, or other body parts. While usually mild, this swelling can be hazardous for individuals with heart failure or kidney problems who need to limit salt intake. Notify your healthcare provider if you experience swelling, shortness of breath, require multiple pillows to sleep, or notice sudden weight gain.

  • Medication Timing: Sodium polystyrene sulfonate (SPS) may interfere with the absorption of other oral medications, reducing their effectiveness. Take other medications at least 3 hours before or after SPS. If you have slow digestion (gastroparesis), you may need to separate SPS and other medications by at least 6 hours.

  • Choking Hazard: There is a risk of choking if the SPS powder is inhaled. Mix the powder thoroughly in water and consume it while sitting upright to minimize this risk. This is particularly important for individuals with an impaired gag reflex or those prone to spitting up.

Contraindications: Do not use this medication if you have low potassium levels, a bowel obstruction, or if it is intended for newborns with gut movement issues. Always consult your healthcare provider before use if any of these conditions apply to you.

Sodium Polystyrene Sulfonate Side Effects

Common side effects:

  • Loss of appetite
  • Nausea
  • Vomiting
  • Constipation
  • Diarrhea

Less common but important to monitor:

  • Gut irritations
  • Gut blockages

Serious side effects:

  • Intestinal necrosis
  • Low electrolyte levels
  • Severe allergic reaction

Sodium Polystyrene Sulfonate Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Interactions with low risk that usually do not require a change in therapy:

Sodium Polystyrene Sulfonate FAQs
Is sodium polystyrene sulfonate the same as Kayexalate?

Yes, sodium polystyrene sulfonate is the generic name for the brand name medication Kayexalate. They are the same medication used to treat high levels of potassium in the blood.

When taking sodium polystyrene sulfonate, it is advisable to avoid foods that are high in potassium. This includes bananas, oranges, tomatoes, potatoes, and spinach. Additionally, it is recommended to avoid using salt substitutes that contain potassium.

Yes, sodium polystyrene sulfonate can cause diarrhea as a side effect. It is important for individuals taking this medication to monitor for gastrointestinal symptoms and consult their healthcare provider if they experience significant or persistent diarrhea.

Yes, sodium polystyrene sulfonate is still used in medical practice. It is commonly prescribed to treat hyperkalemia, a condition characterized by elevated levels of potassium in the blood.

Yes, Kayexalate can induce diarrhea as a side effect. It is a medication used to treat high potassium levels in the blood, and gastrointestinal disturbances, including diarrhea, are common side effects. If diarrhea becomes severe or persistent, it is advisable to consult a healthcare professional.