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Spritam (levetiracetam) is a medication with several important safety considerations. Patients and healthcare providers should be aware of the following potential risks and precautions when using this drug:

• Mood and Behavioral Changes: This medication may alter your mood, thoughts, or behavior, causing irritability, aggression, anxiety, paranoia, or depression. Those with a history of mental health disorders, such as depression, schizophrenia, or bipolar disorder, should be particularly cautious. Report any unusual mood changes to your healthcare provider.

• Risk of Suicidal Thoughts: Antiepileptic drugs like Spritam can increase the risk of suicidal thoughts or behaviors. This risk may emerge within a week of starting the medication. If you or someone around you notices signs of worsening depression or suicidal thoughts, contact your healthcare provider immediately. In emergencies, call 911.

• Drowsiness and Coordination Issues: Users may experience sleepiness, fatigue, and concentration or coordination difficulties, especially during the first month of treatment. These effects could be exacerbated if you are taking other medications that cause drowsiness or dizziness.

• Serious Allergic Reactions: Severe allergic reactions, including drug reactions with eosinophilia and systemic symptoms (DRESS), anaphylaxis, and serious skin reactions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), can occur. Seek immediate medical attention if you experience severe swelling or skin reactions.

• Withdrawal Seizures: Abruptly stopping Spritam can result in withdrawal seizures or status epilepticus, a medical emergency. Always consult your healthcare provider before discontinuing the medication, as they will typically taper your dose gradually to prevent complications.

• Low Blood Cell Counts: Although rare, Spritam can cause a reduction in blood cell counts, leading to symptoms like unusual weakness, persistent infections, or abnormal bleeding. Contact your healthcare provider if you experience these symptoms. Regular blood tests may be necessary to monitor your blood cell levels.

• Increased Blood Pressure in Young Children: In children under 4 years of age, Spritam may cause elevated blood pressure. This effect has not been observed in older children or adults. Close monitoring is advised for this age group.

Consult your healthcare provider for personalized advice and report any concerning symptoms as soon as they arise.

When taking Spritam, it's important to be aware of potential interactions with other substances:

Alcohol: Consuming alcohol while on Spritam can enhance side effects like dizziness, drowsiness, and difficulty concentrating. It's advisable to avoid or limit alcohol intake during treatment.

Medications: Spritam may interact with certain drugs, leading to increased sedation or other effects. Notable interactions include:

• Azelastine: Combining with Spritam can heighten central nervous system depression.

• Ethanol: Concurrent use may amplify sedative effects.

• Oliceridine: Co-administration can raise the risk of low blood pressure, sedation, and respiratory depression.

• Thalidomide: Using together may increase central nervous system depression.

Additionally, Spritam can interact with medications like Carbamazepine, Colesevelam, Probenecid, and sevelamer. These interactions can affect how Spritam or the other drugs work, potentially leading to increased side effects or reduced effectiveness.

Health Conditions: Certain medical conditions can influence how Spritam affects you:

• Kidney Disease: Impaired kidney function may alter how Spritam is processed in the body.

• Mental Health Issues: Conditions like depression or a history of suicidal thoughts can be affected by Spritam.

Always inform your healthcare provider about all medications, supplements, and health conditions before starting Spritam to ensure safe and effective treatment.