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This safety information outlines crucial warnings and precautions for those considering the use of sumatriptan (Imitrex). It is vital to familiarize yourself with these details to ensure safe use and to consult your healthcare provider if you have any questions or concerns.

• Heart and Blood Pressure Risks: Sumatriptan (Imitrex) may cause serious heart complications, including heart attacks and irregular heartbeats, particularly within hours of ingestion. It can also elevate blood pressure, potentially to hazardous levels. Individuals with a history of heart issues, or those over the age of 65, with diabetes, obesity, or high blood pressure, and smokers or those with a family history of heart disease should consult their healthcare provider prior to use. Regular monitoring of blood pressure is recommended. Seek immediate medical attention if you experience symptoms like chest pain, severe headache, or irregular heartbeat.

• Stroke and Brain Injury Risks: The medication has been associated with life-threatening strokes or brain bleeding. Symptoms such as sudden weakness, severe headaches, facial drooping, breathing difficulties, or changes in speech or vision necessitate immediate medical evaluation, as they may mimic migraine symptoms. Individuals with a history of strokes should avoid using sumatriptan (Imitrex).

• Vascular Constriction: This medication may cause severe narrowing of blood vessels, leading to abdominal pain, bloody diarrhea, vision disturbances, and altered sensations or color changes in extremities. Discontinue use and consult a healthcare provider if these symptoms occur.

• Serotonin Syndrome: There is a risk of developing serotonin syndrome, a potentially fatal condition, especially when combined with other medications that increase serotonin levels, such as certain antidepressants and migraine medications.

• Allergic Reactions: Potential allergic reactions include facial swelling, shock, and anaphylaxis, which require immediate medical attention if symptoms like dizziness, breathing difficulties, or swelling are observed.

• Seizures: The risk of seizures exists, even for those without a previous history. Individuals with a history of seizures should be particularly cautious.

Contraindications: Do not use sumatriptan (Imitrex) if you have:

• Coronary artery disease.
• Specific heart rhythm disorders.
• A history of stroke or transient ischemic attack.
• Hemiplegic or basilar migraines.
• Peripheral vascular disease.
• Ischemic bowel disease.
• Uncontrolled high blood pressure.
• Recently used ergot-containing medications or other triptans.
• Taken MAOIs within the past 14 days.
• Severe liver issues.

If any of these conditions apply to you, it is crucial to consult with your healthcare provider before using this medication.

Common side effects:

• Flushing
• Feelings of tingling or numbness in the fingers or toes
• Sensations of heat or cold
• Fatigue
• Tiredness
• Weakness
• Drowsiness
• Dizziness

Less common but important to monitor:

• Chest, jaw, or neck tightness, pain, or pressure
• Chest pain
• Shortness of breath
• Unusual sweating

Serious side effects:

• Heart attack
• Dangerously high blood pressure
• Symptoms of a stroke
• Serotonin syndrome
• Allergic reactions
• Seizures
• Severe stomach pain
• Bloody diarrhea
• Changes in speech or vision

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (e.g., isocarboxazid, Linezolid, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)
• Ergotamine medications (e.g., Dihydroergotamine)
• Other "triptan" drugs (e.g., Zolmitriptan, Rizatriptan)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• SSRIs (e.g., Fluoxetine, paroxetine)
• SNRIs (e.g., Duloxetine, Venlafaxine)
• Street drugs like MDMA
• St. John's wort