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When taking this medication, you might experience some common side effects like flushing, tingling, numbness, tiredness, or dizziness. These are usually mild but if they persist or worsen, it's important to consult a healthcare professional. This medication can also increase blood pressure, so regular monitoring is recommended. Contact a healthcare provider if you notice high blood pressure readings.

Be aware of serious side effects, which require immediate medical attention. These include blue discoloration of fingers or toes, cold extremities, changes in hearing, or mood alterations. Sumatriptan may cause chest, jaw, or neck tightness, which is typically not serious but can resemble heart attack symptoms like chest pain, shortness of breath, or unusual sweating. Seek emergency help if these occur, as well as for fast or irregular heartbeat, fainting, severe stomach pain, bloody diarrhea, seizures, or signs of a stroke.

This medication can also increase serotonin levels, potentially leading to serotonin syndrome, a rare but serious condition. Symptoms to watch for include rapid heartbeat, hallucinations, lack of coordination, severe dizziness, nausea, vomiting, muscle twitching, fever, or agitation. An allergic reaction is rare but requires urgent medical assistance if you experience rash, itching, swelling, severe dizziness, or difficulty breathing.

This list is not exhaustive; if you observe other side effects, contact a healthcare professional for advice.

Using MAO inhibitors with this medication can lead to a severe and possibly life-threatening interaction. Avoid taking any MAO inhibitors, such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, or Tranylcypromine, while on this treatment. Additionally, most MAO inhibitors should not be used for two weeks before starting this medication. Consult your doctor for guidance on when to begin or discontinue this medication.

The risk of developing serotonin syndrome or toxicity is higher if you take other drugs that increase serotonin levels. These include certain recreational drugs like MDMA/"ecstasy," St. John's wort, and some antidepressants like SSRIs (e.g., Fluoxetine, paroxetine) and SNRIs (e.g., Duloxetine, Venlafaxine). The likelihood of serotonin syndrome/toxicity may increase when you start or raise the dosage of these medications.

If you are also using ergotamine medications (such as Dihydroergotamine) or other "triptan" drugs (such as Zolmitriptan, Rizatriptan), it is important to space out your sumatriptan dose from these medications to reduce the risk of severe side effects. Consult your doctor to determine the appropriate interval between doses.