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It is crucial to adhere to the following safety guidelines and warnings when using this medication. These instructions help manage potential risks and ensure the medication is used safely and effectively.

• Consultation Before Discontinuation: Do not abruptly stop taking this medication without consulting your healthcare provider, as it may worsen certain conditions. Sudden cessation may lead to chest pain, heart attack, or irregular heartbeat. If discontinuation is necessary, your doctor will guide you to reduce the dosage gradually over one to two weeks. During this period, it is advisable to limit physical activity to reduce heart strain. Seek immediate medical attention if you experience chest pain, pressure, or pain radiating to the jaw, neck, or arm, excessive sweating, breathing difficulties, or a rapid or irregular heartbeat.

• Heart Failure Risk: Although rare, some individuals have developed heart failure while using timolol. Existing heart conditions may worsen. Inform your healthcare team of your medical history and promptly report any swelling in your feet or ankles, rapid or irregular pulse, or shortness of breath, as these could indicate heart issues. Risks include congestive heart failure and heart block.

• Respiratory Concerns: Beta blockers like timolol are generally not recommended for individuals with respiratory issues such as asthma or COPD, as they can narrow airways and exacerbate breathing difficulties. Ensure your healthcare provider is aware of any lung problems to evaluate the safety of this medication for you.

• Diabetes and Hidden Low Blood Sugar Symptoms: Timolol may obscure symptoms of low blood sugar in diabetic patients, except for sweating and dizziness. Discuss with your healthcare provider whether you should monitor your blood sugar more frequently while on timolol.

• Thyroid Disease and Masked Symptoms: Timolol may also obscure signs of an overactive thyroid, such as a rapid heartbeat. Inform your healthcare provider if you have thyroid issues before starting the medication.

• Myasthenia Gravis Concerns: Rarely, timolol may worsen symptoms such as muscle weakness in individuals with myasthenia gravis. Monitor your symptoms closely and report any worsening to your healthcare provider.

Contraindications

Avoid using this medication if you have any of the following conditions, as it may pose serious health risks. Always consult your healthcare provider:

• Asthma
• Severe COPD
• Sinus bradycardia
• Second- or third-degree heart block
• Heart failure
• Cardiogenic shock

Adhering to these guidelines will help ensure the safe and effective use of the medication, minimizing potential risks and complications.

Common side effects:

• Tiredness
• Dizziness
• Slow heartbeat
• Temporary burning or stinging in the eyes
• Red eyes
• Crusty lashes
• Eye pain
• Feeling of something in the eye

Less common but important to monitor:

• Decrease in sexual ability
• Reduced blood flow to the hands and feet
• Cold sensation in hands and feet
• Itchy eyes
• Increase in tears
• Changes in vision
• Double vision
• Headaches
• Dizziness

Serious side effects:

• Very slow heartbeat
• Fainting
• Blue fingers or toes
• New or worsening symptoms of heart failure
• Mental or mood changes
• Severe allergic reactions

Interactions with high risk of serious adverse effects and should be avoided:

• Fingolimod

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Albuterol
• Ceritinib
• Crizotinib
• Dronedarone
• Fenoldopam
• Formoterol
• Indacaterol
• Iobenguane I 131
• Iohexol
• Lacosamide
• Levalbuterol
• Olodaterol
• Oxymetazoline
• Paroxetine
• Ponesimod
• Rivastigmine
• Salmeterol
• Terbutaline
• Vilanterol

Interactions with low risk that usually do not require a change in therapy:

• Aceclofenac
• Acemetacin
• Amtolmetin Guacil
• Aspirin
• Bromfenac
• Bufexamac
• Celecoxib
• Choline Salicylate
• Clonixin
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Dipyrone
• Droxicam
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Ibuprofen
• Indomethacin
• Ketoprofen
• Ketorolac
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Morniflumate
• Nabumetone
• Naproxen
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Phenylbutazone
• Piketoprofen
• Piroxicam
• Pranoprofen
• Proglumetacin
• Propyphenazone
• Proquazone
• Rofecoxib
• Salicylic Acid
• Salsalate
• Sodium Salicylate
• St John's Wort
• Sulindac
• Tenoxicam
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Valdecoxib