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You might experience mild side effects such as nausea, vomiting, headaches, bloating, breast tenderness, fluid retention leading to swelling of ankles or feet, or changes in weight. It's also common to have spotting or irregular periods, especially in the initial months. These effects are generally manageable, but consult your healthcare provider if they persist or worsen.

This medication could potentially increase your blood pressure, so regular monitoring is advisable. Please inform your healthcare provider if you notice elevated readings. Serious side effects, though uncommon, can occur. These include significant changes in vaginal bleeding patterns, symptoms indicating high potassium levels like muscle weakness or irregular heartbeat.

In rare instances, the medication might lead to severe conditions such as blood clots, posing risks of a heart attack, stroke, or clots in the lungs or legs. Seek emergency assistance if you experience symptoms like difficulty breathing, chest pain, sudden dizziness, swelling in the calf, or severe headaches. Furthermore, watch for serious signs such as breast lumps, intense abdominal pain, dark urine, jaundice, or significant mood changes.

Allergic reactions are rare but can be serious. Immediate medical help is necessary if you develop a rash, swelling, severe dizziness, or difficulty breathing. If you encounter any other unusual effects, consult your healthcare provider.

Some products that might interact with this medication include aromatase inhibitors (like Anastrozole and Exemestane), atazanavir/cobicistat, fezolinetant, Fosamprenavir, ospemifene, Tamoxifen, Tizanidine, Tranexamic Acid, and certain combination treatments for chronic hepatitis C (such as ombitasvir/paritaprevir/Ritonavir, with or without dasabuvir). Drospirenone can increase potassium levels in your blood. Inform your doctor if you regularly use other medications that raise potassium levels, such as Aliskiren, ACE inhibitors (like Enalapril and Lisinopril), angiotensin receptor blockers (like Losartan and Valsartan), heparin, NSAIDs (like Ibuprofen and Naproxen), and potassium-sparing diuretics or "water pills" (such as Eplerenone, Spironolactone, and Triamterene).

Certain medications can reduce the effectiveness of hormonal birth control by lowering hormone levels in your body, which may lead to pregnancy. Examples include griseofulvin, Modafinil, rifamycins (such as Rifampin), ritonavir, St. John's wort, and drugs used for seizures (such as barbiturates, Carbamazepine, Felbamate, Phenytoin, Primidone, and Topiramate), as well as some HIV medications (like nelfinavir and Nevirapine). It is important to consult your doctor or pharmacist for more information. Always inform your doctor when starting any new medication and discuss whether you should use additional birth control methods. If you experience new spotting or breakthrough bleeding, notify your doctor, as these can indicate reduced effectiveness of your birth control.

Additionally, this medication might interfere with certain lab tests, potentially leading to incorrect test results. Ensure that lab personnel and all your healthcare providers are aware that you are using this medication.