
Tetrabenazine Coupons & Savings Card – Discount Prices from $37.70
Generic for: Xenazine
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12.5MG, Tetrabenazine (30 Tablets)
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Rite Aid
$37.70
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Walgreens
$54.90
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Albertsons
$576.42
COUPON PRICETetrabenazine savings card
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Rite Aid
$37.70
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More prescriptions for Huntington's chorea
More prescriptions for Huntington's chorea
Tetrabenazine dosage forms
Dosage | Quantity | Price from | Per unit |
---|---|---|---|
25MG | 30 Tablets | $47.1 | $1.57 |
12.5MG | 30 Tablets | $37.7 | $1.26 |
Tetrabenazine Warnings
Tetrabenazine, also known as Xenazine, is a medication that requires careful consideration of its safety and potential risks. Below is important information you need to know before using this medication. Please ensure to discuss any concerns with your healthcare provider.
Depression and Suicidal Thoughts: Tetrabenazine may increase the risk of depression and suicidal thoughts, particularly in individuals with Huntington's disease. It is crucial for healthcare providers to monitor patients for these symptoms throughout treatment. If you or those around you notice any signs such as worsening depression, suicidal thoughts, anxiety, panic attacks, or changes in behavior, contact your healthcare provider immediately. Discontinuation of the medication may be necessary if symptoms persist.
Huntington's Disease Symptoms: Tetrabenazine can potentially worsen some symptoms of Huntington's disease, such as mood changes, cognitive difficulties, and muscle stiffness. Regular assessments by your healthcare provider are essential to determine the medication's safety and effectiveness. Adjustments in dosage or a temporary discontinuation of the medication may be needed based on symptom evaluation.
Genetic Testing for Dosage: For those who require more than 50 mg of tetrabenazine daily, genetic testing might be necessary to assess how your body metabolizes the drug. Based on the test results, your dosage may be adjusted to improve treatment effectiveness.
Neuroleptic Malignant Syndrome (NMS): This medication can cause a rare but serious condition called NMS, characterized by high fever, muscle stiffness, confusion, and irregular heartbeat. The risk increases with the use of other medications such as antipsychotics. Immediate medical attention is required if symptoms occur.
Movement Disorders (Parkinsonism): Tetrabenazine may cause restlessness, agitation, or a condition known as akathisia. If these symptoms arise, consult your healthcare provider.
Heart Rhythm Abnormalities (QT Prolongation): Although rare, tetrabenazine can lead to QT prolongation, affecting heart rhythms. Those with low heart rates, low potassium or magnesium levels, or those taking other QT-prolonging drugs are at higher risk. Any symptoms like chest pain, fainting, or shortness of breath should be treated as emergencies.
High Prolactin Levels: The drug may increase prolactin levels, potentially leading to breast growth or milk production in both sexes, and may affect bone density and sexual interest. Notify your healthcare provider if you experience these symptoms.
Contraindications: Do not use tetrabenazine if you have untreated or unresolved depression, suicidal thoughts, liver failure, or if you are taking MAOIs or other similar medications such as Austedo or Ingrezza. Always consult your healthcare provider before starting or stopping any medication.
Tetrabenazine Side Effects
Common side effects:
- drowsiness
- trouble sleeping
- tiredness
- dizziness
- nausea
- vomiting
mild mood changes such as anxiety or irritability
Less common but important to monitor:
- headache
- slurred speech
- unsteady gait
- shortness of breath
- low appetite
- feelings of restlessness
increase in depression symptoms
Serious side effects:
- neuroleptic malignant syndrome symptoms (high fever, muscle stiffness, severe confusion, abnormal heart rhythms)
- severe mood changes
- suicidal thoughts
- chest pain
- difficulty breathing
- serious allergic reactions (rash, swelling, trouble breathing)
Tetrabenazine Interactions
Tetrabenazine (Xenazine) can interact with other medications or supplements. It is important to inform your doctor and pharmacist about all the medications and supplements you are currently taking, including prescription, over-the-counter, vitamins, and herbal products. Below are some key interactions to be aware of:
MAO Inhibitors: Combining tetrabenazine with MAO inhibitors, such as isocarboxazid, linezolid, phenelzine, and others, can lead to a serious and potentially fatal drug interaction. Avoid using MAO inhibitors during treatment with tetrabenazine and for two weeks before and after its use. Consult with your doctor on when to start or stop these medications.
Similar Medications: Tetrabenazine should not be used with deutetrabenazine as they are very similar. Using both can increase the risk of side effects.
Other Drug Interactions: The use of tetrabenazine with certain medications like valbenazine, bepridil, and others listed in the sources is not recommended. Your doctor may choose alternative treatments or adjust your medications accordingly.
Potential Side Effects: Some drugs, such as paroxetine, may increase the risk of side effects when used with tetrabenazine. Your doctor may need to adjust dosages or monitor your usage carefully if these are prescribed together.
Always consult with your healthcare provider to ensure safe and effective use of tetrabenazine alongside other treatments.
Is tetrabenazine an antipsychotic?
Tetrabenazine is not classified as an antipsychotic. It is a medication primarily used to treat movement disorders, such as those associated with Huntington's disease.
Who should not use tetrabenazine?
Tetrabenazine should not be used by individuals with untreated or inadequately treated depression, those with suicidal thoughts, or those with hepatic impairment. It is also contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) or reserpine. Additionally, individuals with a known hypersensitivity to tetrabenazine or any of its components should avoid using it. It is important for patients to consult with their healthcare provider to determine if tetrabenazine is appropriate for their condition.
What does tetrabenazine do to the brain?
Tetrabenazine works by depleting dopamine, serotonin, and norepinephrine in the brain. It inhibits the vesicular monoamine transporter 2 (VMAT2), which is responsible for packaging these neurotransmitters into vesicles for release into the synaptic cleft. This action reduces the levels of these neurotransmitters, which can help manage conditions like chorea associated with Huntington's disease.
What drugs interact with tetrabenazine?
Tetrabenazine can interact with several types of medications. These include:1. Monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromine.2. Antidepressants, particularly those that affect serotonin levels, like SSRIs and SNRIs.3. Antipsychotic medications.4. Certain heart medications, such as those that affect heart rhythm.5. Strong CYP2D6 inhibitors, which can increase tetrabenazine levels in the body.It is important for individuals to consult with their healthcare provider before starting or stopping any medications while taking tetrabenazine.
What are the side effects of tetrabenazine?
Tetrabenazine may cause several side effects. Common side effects include drowsiness, fatigue, insomnia, depression, anxiety, and nausea. Some individuals may experience dizziness, restlessness, or changes in appetite. More serious side effects can include worsening depression, suicidal thoughts, or changes in mood. It is important for individuals taking tetrabenazine to be monitored by their healthcare provider for any adverse effects.