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Here are the important safety and warning considerations for those using deutetrabenazine (Austedo), particularly for individuals with Huntington's disease. Please review these points with your healthcare provider to understand any potential risks and precautions:

• Depression and Suicidal Thoughts: Deutetrabenazine can heighten the risk of depression and suicidal ideation, especially in individuals with Huntington's disease. It is crucial to discuss these risks with your doctor before starting the medication. Continuous monitoring for signs of depression or suicidal thoughts is advised. If you or your caregivers observe any new or worsening symptoms, such as increased sadness, lack of interest in usual activities, panic attacks, or irritability, contact your healthcare provider immediately.

• Worsening Huntington's Disease Symptoms: Symptoms like mood changes and cognitive difficulties can overlap with the side effects of deutetrabenazine. Regular evaluations by your healthcare provider are necessary to ensure the medication is effective and safe. Your provider may adjust your dosage to discern whether these symptoms stem from the disease or the medication.

• Heart Rhythm Concerns (QT Prolongation): Although rare, deutetrabenazine can cause QT prolongation, affecting heart rhythm. Your doctor may advise against using deutetrabenazine if you have existing heart rhythm issues or are taking other QT-prolonging medications. Seek immediate medical attention if you experience chest pain, trouble breathing, or lightheadedness.

• Neuroleptic Malignant Syndrome (NMS) Risk: While not reported with deutetrabenazine, a similar medication has caused NMS, a serious condition. Be cautious if you're using antipsychotic drugs or medications that lower dopamine levels.

• Movement Disorders (Parkinsonism): Deutetrabenazine may lead to restlessness or agitation, known as akathisia. Notify your provider if these symptoms occur.

• High Prolactin Levels: Although not specifically studied with deutetrabenazine, a similar medication may raise prolactin levels, potentially causing breast growth or milk production. Consult your provider if you notice these changes.

Contraindications:

• Avoid deutetrabenazine if you have untreated depression or suicidal tendencies, liver issues, or if you've used monoamine oxidase inhibitors (MAOIs) like selegiline or phenelzine in the past 14 days.
• Do not use alongside tetrabenazine or Ingrezza (valbenazine).

In case of an overdose, seek emergency medical assistance immediately. Always follow your healthcare provider's advice and report any unusual symptoms or concerns promptly.

When taking this medication, some individuals may experience common side effects such as drowsiness, trouble sleeping, tiredness, dizziness, nausea, or vomiting. These effects are generally mild, but if they persist or worsen, it's important to inform your healthcare provider. Adjustments to your dosage might be necessary to alleviate these symptoms. To minimize dizziness or lightheadedness, try getting up slowly from sitting or lying down positions. An empty tablet shell in your stool is harmless, as your body has already absorbed the medication.

While most people do not experience severe side effects, it's crucial to be aware of them. Serious side effects to watch for include agitation, restlessness, and symptoms resembling Parkinson's disease like shaking, tremors, or difficulty with movement and balance. Sometimes, the medication can mimic or exacerbate symptoms of Huntington's disease, such as mental or mood changes, including depression or suicidal thoughts, trouble swallowing, and uncontrolled facial movements. If you notice signs of increased prolactin hormone, such as changes in breast tissue or menstrual cycles, inform your doctor immediately.

In rare instances, the medication may lead to neuroleptic malignant syndrome (NMS), a serious condition requiring immediate medical attention. Symptoms include fever, muscle stiffness, severe tiredness, confusion, sweating, irregular heartbeat, dark urine, and signs of kidney issues. Additionally, although uncommon, serious allergic reactions can occur with symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing. These require urgent medical care. Always contact your healthcare provider if you notice any unusual effects, even if they are not listed here.