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When using deutetrabenazine, especially for individuals with Huntington's disease, it's crucial to be aware of certain safety considerations due to the potential mental health risks associated with this medication. Here are key points to keep in mind:

• Increased Risk of Depression and Suicidal Thoughts: Deutetrabenazine may elevate the risk of depression and suicidal thoughts or attempts, particularly in individuals with Huntington's disease, who are already at a higher risk for these issues.
• Discussion with Healthcare Provider: Engage in a comprehensive discussion with your healthcare provider to weigh the risks and benefits of using deutetrabenazine.
• Contraindication for Certain Patients: Those with Huntington's disease and existing depression should not use deutetrabenazine if they are not actively undergoing treatment for depression or if depressive symptoms persist despite treatment.
• Monitoring for Mental Health Changes: It's vital to promptly inform your doctor if you or those around you observe any new or worsening signs of depression, sadness, lack of interest in previously enjoyed activities, suicidal thoughts or attempts, or any other changes in mood or behavior, including increased anxiety, panic attacks, sleep disturbances, irritability, or hostility.

By staying vigilant and maintaining open communication with your healthcare provider, you can help manage the potential risks associated with deutetrabenazine effectively.

When taking this medication, you might experience common side effects such as drowsiness, trouble sleeping, tiredness, dizziness, nausea, or vomiting. These are generally mild and should ease with time. To alleviate dizziness, rise slowly from sitting or lying positions. Occasionally, you may notice an empty tablet shell in your stool, which is harmless as the medicine has already been absorbed.

It's important to be aware of more serious side effects, although they are less common. Contact a healthcare professional if you experience persistent agitation, restlessness, or symptoms resembling Parkinson's disease, such as tremors or balance issues. These symptoms could sometimes be confused with those of worsening Huntington's disease, so dose adjustments might be necessary.

Be vigilant for mental or mood changes, including depression or suicidal thoughts, as well as trouble swallowing or uncontrolled facial muscle movements. Additionally, signs of increased prolactin, such as breast changes or menstrual irregularities, should be reported promptly.

Rarely, this medication can cause a severe condition known as neuroleptic malignant syndrome (NMS). Seek immediate medical attention if you experience symptoms like fever, muscle pain, severe confusion, or irregular heartbeat. An allergic reaction is also rare but requires urgent care if you notice rash, swelling, or trouble breathing.

This summary covers many, but not all, potential side effects. If you experience any unusual symptoms, it's crucial to consult with a healthcare provider.