
Tolcapone Coupons & Discount Card - Compare Prices Near You
generic Tasmar
My prescription
Edit
100MG, Tolcapone (30 Tablets)
Select pharmacy

CVS
$373.02
COUPON PRICE
Walgreens
$349.55
COUPON PRICE
Albertsons
$403.26
COUPON PRICE
Rite Aid
$1103.53
COUPON PRICE
Walmart
$1114.85
COUPON PRICETolcapone savings card
Show this card to your pharmacist
CVS
$373.02
BIN
ID
PCN
GRP
019876
LH5839D2CA
CHIPPO
LHX
Powered by
Tolcapone dosage forms
Dosage | Quantity | Price from | Per unit |
---|---|---|---|
100MG | 30 Tablets | $412.95 | $13.76 |
Tolcapone Warnings
Tolcapone (Tasmar) is a medication used to manage Parkinson’s disease symptoms, particularly when levodopa effects wane between doses. However, it carries significant risks, especially concerning liver health, and should be used with caution. Below are important safety considerations and warnings associated with its use.
Liver Risk: Tolcapone can lead to severe and potentially fatal liver damage. It should not be used by individuals with existing liver disease or those who have experienced liver damage from tolcapone in the past. Regular liver function tests are mandatory before and during treatment. Inform your healthcare provider immediately if you notice symptoms like persistent nausea, vomiting, abdominal pain, dark urine, extreme fatigue, loss of appetite, yellowing of the skin or eyes, or pale stools.
Sleepiness: This medication may cause sudden sleep onset, even during activities. Avoid driving or engaging in tasks requiring alertness until you know how tolcapone affects you. If you have a history of drowsiness, discuss this with your physician.
Blood Pressure Changes: Tolcapone may cause sudden drops in blood pressure upon standing, leading to dizziness, falls, or fainting. Rise slowly from sitting or lying positions and steady yourself on a solid object. Report any incidents of fainting or dizziness to your healthcare provider.
Mental Health Effects: Some users experience hallucinations, paranoia, confusion, or changes in behavior and thoughts. These effects often appear shortly after starting the medication or adjusting the dose. If you experience any of these symptoms, contact your healthcare provider, who may adjust your dosage.
Impulsive Behaviors: There is a risk of increased impulsivity, such as compulsive gambling, eating, or spending. Discuss any behavior changes with your provider.
Muscle Damage: Severe muscle damage, leading to kidney issues, has been reported. Seek medical attention if you experience muscle pain, cramping, or dark urine.
Contraindications:
- Do not use tolcapone if you have liver issues or a history of liver or muscle damage, high fever, or confusion related to tolcapone use.
In case of an overdose, seek emergency medical attention immediately. Always follow your healthcare provider's guidance and report any adverse reactions or concerns during treatment.
Tolcapone Side Effects
Common side effects:
- nausea
- involuntary movements
- sleep issues
- excessive dreaming
- muscle contractions or cramps
- loss of appetite
- sleepiness
- low blood pressure
- diarrhea
- dizziness
- confusion
- headache
- dry mouth
- increased sweating
- abdominal discomfort
Less common but important to monitor:
- tiredness
- fainting
- stomach upset
- vomiting
- constipation
- falling
- bladder infection
- symptoms resembling a common cold or flu
Serious side effects:
- significant liver damage (jaundice, pale stools, dark urine)
- severe muscle damage (rhabdomyolysis, muscle aches, dark-colored urine)
- neuroleptic malignant syndrome (very high fevers, irregular pulse, muscle stiffness)
- very serious allergic reaction (rash, severe dizziness, trouble breathing)
Tolcapone Interactions
Interactions with high risk of serious adverse effects and should be avoided:
- Isocarboxazid
- Linezolid
- Phenelzine
- Procarbazine
- Tranylcypromine
- Iproniazid
- Nialamide
- Pargyline
Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:
- Safinamide
- Selegiline
- Rasagiline
- Apomorphine
- Dobutamine
- Methyldopa
Interactions with low risk that usually do not require a change in therapy:
- Alcohol
- Marijuana
- Antihistamines (e.g., cetirizine, diphenhydramine)
- Sleep or anxiety medications (e.g., alprazolam, diazepam, zolpidem)
- Muscle relaxants
- Opioid pain relievers (e.g., codeine)
What is tolcapone used for?
Tolcapone is used as an adjunct treatment for patients with Parkinson's disease. It is specifically used to manage symptoms in individuals who are experiencing fluctuations in the effectiveness of their primary Parkinson's medication, typically levodopa/carbidopa. Tolcapone works by inhibiting the enzyme catechol-O-methyltransferase (COMT), which helps to prolong the effect of levodopa.
What is the mechanism of action of tolcapone?
Tolcapone is a medication that works by inhibiting the enzyme catechol-O-methyltransferase (COMT). This enzyme is involved in the breakdown of dopamine. By inhibiting COMT, tolcapone increases the levels of dopamine in the brain, which helps improve the symptoms of Parkinson's disease.
Is tolcapone toxic to the liver?
Yes, tolcapone can be toxic to the liver. It has been associated with cases of severe liver injury, including fatal liver failure. Therefore, liver function should be monitored regularly in patients taking tolcapone, and it is typically used only when other treatments are not effective.
Does tolcapone increase dopamine?
Yes, tolcapone increases dopamine levels in the brain. It works by inhibiting the enzyme catechol-O-methyltransferase (COMT), which breaks down dopamine. By inhibiting this enzyme, tolcapone helps to maintain higher levels of dopamine, which can be beneficial in managing symptoms of Parkinson's disease.
Who should not take tolcapone?
Tolcapone should not be taken by individuals with liver disease or a history of liver problems, as it can cause liver damage. It is also contraindicated in patients who have shown hypersensitivity to tolcapone or any of its components. Additionally, it should not be used in patients with a history of non-traumatic rhabdomyolysis or hyperpyrexia and confusion possibly related to medication. It is important for patients to discuss their full medical history with their healthcare provider before starting tolcapone.