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The following information outlines critical safety warnings associated with the use of Tigan (trimethobenzamide). Please read carefully and consult your healthcare provider for any concerns.

• Movement Issues: Tigan may induce sudden involuntary muscle spasms, particularly in the head and neck, and can also lead to symptoms similar to Parkinson's disease, such as tremors, restlessness, and difficulties with swallowing or speaking. If you experience these symptoms, contact your healthcare provider. They may adjust your dosage or discontinue the medication. Caution is advised if you are taking other medications that may cause movement problems.

• Cognitive Impairment: This medication can cause drowsiness and impair cognitive functions, affecting your ability to drive or operate heavy machinery safely. Some users have reported mood changes, confusion, seizures, and in rare cases, coma. If you notice any mood or behavioral changes, contact your healthcare provider immediately. Inform your family and caregivers about these risks so they can seek help on your behalf if necessary. Avoid combining Tigan with sedatives, alcohol, opioids, or anticholinergics, as this may increase these risks.

• Potential Masking of Serious Conditions: The side effects related to movement and cognition could indicate more severe, undiagnosed health issues. If you experience changes in movement, mood, or behavior while taking Tigan, consult your healthcare provider to rule out other conditions.

• Liver Health: Tigan may adversely affect liver function. Blood tests may be required before starting the medication to ensure there is no pre-existing liver damage. Immediately contact your healthcare provider if you notice symptoms such as jaundice, abdominal pain, or dark urine, especially if you have a history of liver problems.

No specific contraindications are noted for Tigan. Always follow your healthcare provider's instructions regarding the use of this medication.

Common side effects:

• Confusion
• Headache
• Drowsiness
• Dizziness
• Blurred vision
• Muscle cramps
• Diarrhea
• Rash
• Tremors

Less common but important to monitor:

• Movement problems
• Muscle spasms
• Restlessness
• Trouble swallowing
• Trouble speaking

Serious side effects:

• Coma
• Depression
• Seizures
• Liver damage
• Yellowing of the skin
• Yellowing of the whites of the eyes
• Abdominal pain
• Dark-colored urine

When taking trimethobenzamide, it's important to be aware of potential interactions with other substances that can affect its effectiveness or increase the risk of side effects. Here are some key interactions to consider:

Alcohol: Consuming alcohol while on trimethobenzamide can enhance drowsiness and dizziness. It's advisable to avoid alcohol during treatment to prevent these effects.

Central Nervous System (CNS) Depressants: Medications that depress the central nervous system, such as sedatives, hypnotics, opioids, anxiolytics, and antipsychotics, can intensify the sedative effects of trimethobenzamide. This combination may lead to increased drowsiness, dizziness, and impaired coordination.

Anticholinergic Agents: Combining trimethobenzamide with anticholinergic drugs (e.g., atropine, Scopolamine) may amplify side effects like dry mouth, blurred vision, constipation, and urinary retention.

Antihistamines: Over-the-counter antihistamines, such as diphenhydramine, can increase drowsiness when taken with trimethobenzamide.

Opioid Pain Relievers: Medications like Tramadol can enhance the sedative effects of trimethobenzamide, leading to increased drowsiness and dizziness.

Potassium Supplements: Taking Potassium Chloride or Potassium Citrate with trimethobenzamide may increase the risk of gastrointestinal irritation or ulcers.

Other Medications: Certain drugs, including Metoclopramide, olopatadine (intranasal), ropeginterferon alfa-2b, and zuranolone, can interact with trimethobenzamide, leading to increased sedation or other side effects.

To ensure safety, always inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are currently taking before starting trimethobenzamide. They can provide guidance on potential interactions and recommend appropriate adjustments to your treatment plan.