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The following safety and warning information is essential for anyone considering the use of Alfuzosin ER (Uroxatral). Please carefully review these details and discuss any concerns with your healthcare provider.

• Orthostatic Hypotension Risk: Alfuzosin ER may cause a significant drop in blood pressure when transitioning from sitting or lying down to standing. This can result in dizziness or fainting, particularly within hours of dosing. The risk increases if taken with other blood pressure or erectile dysfunction drugs, or if you have a history of low blood pressure. Exercise caution when engaging in activities, especially when starting or adjusting your dosage.

• Medication Interactions: Inform your healthcare provider of all medications you are currently taking, as Alfuzosin ER can interact with several other drugs.

• Liver and Kidney Health Caution: This medication is processed by the liver. It is not recommended for individuals with moderate to severe liver issues. Consult your healthcare provider to evaluate the severity of your liver condition before use.

• Heart Health Considerations: Report any chest pain or heart rhythm disorders (such as long QT syndrome) to your provider. Alfuzosin ER may be discontinued if chest pain occurs or worsens, and heart monitoring might be necessary if you have rhythm issues.

• Priapism Warning: In rare instances, Alfuzosin ER can cause priapism, a painful erection lasting more than four hours. Seek immediate medical attention to prevent permanent erectile dysfunction.

• Surgical Eye Concerns: If you are scheduled for cataract surgery, notify your healthcare provider about your use of Alfuzosin ER. Though the risk is lower than with similar medications, it can cause Intraoperative Floppy Iris Syndrome (IFIS). Your surgeon may need to adjust the surgical technique accordingly.

Contraindications include:

• Known allergy to Alfuzosin ER.
• Impaired liver function.
• Concurrent use of medications that may interact adversely with Alfuzosin ER.

For any of the above conditions, consult your healthcare provider before starting treatment with this medication.

When taking this medication, some individuals may experience dizziness or lightheadedness, which can often be managed by standing up slowly from sitting or lying down. These effects are usually mild, but if they persist or worsen, consulting a healthcare provider is advised. Common side effects also include upper respiratory tract infections, headaches, and fatigue, each occurring in a small percentage of users.

Additional side effects reported include pain, upset stomach, constipation, nausea, erectile dysfunction, inflamed lungs or sinuses, and sore throat. While these are generally not severe, it is important to monitor your symptoms and speak with a healthcare professional if they become bothersome.

Serious side effects, though rare, demand immediate medical attention. These include severe dizziness, fainting, fast or irregular heartbeat, chest pain, and priapism—an erection lasting more than four hours. An allergic reaction to the drug is also possible but uncommon. Symptoms such as rash, itching, swelling, severe dizziness, or trouble breathing require urgent care.

While many people do not experience serious side effects, it is crucial to remain vigilant and seek medical advice if any unexpected symptoms occur. Always prioritize your health and reach out to a healthcare provider for guidance tailored to your situation.

Alfuzosin, known by the brand name Uroxatral, can interact with various medications, which may alter its effects or increase the risk of side effects. It is essential to inform your doctor and pharmacist about all the medications and supplements you are taking, including over-the-counter drugs, vitamins, and herbal products.

Some interactions to be aware of include combining alfuzosin with other alpha blockers like prazosin or terazosin, which is generally not advised unless specifically recommended by your doctor. If you are also taking medications for erectile dysfunction or pulmonary hypertension, such as sildenafil or tadalafil, there is a risk of significantly lowering your blood pressure, which could lead to dizziness or fainting. Your doctor may need to modify your medication regimen to prevent this.

In addition, certain drugs can affect how alfuzosin is removed from your body, potentially impacting its effectiveness. These include azole antifungals like itraconazole and ketoconazole, antibiotics like clarithromycin, and medications used for HIV such as ritonavir and lopinavir, among others.

Always consult your healthcare provider before making any changes to your medication to ensure safe and effective treatment.