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The following safety information is essential for anyone using this medication. Please read it thoroughly and discuss any concerns with your healthcare provider.

• Liver Function Monitoring: While ursodiol (Actigall) is not known to cause liver damage, it is crucial for healthcare providers to assess your liver function before beginning treatment and continue monitoring during its use. Report any signs of liver issues, such as yellowing of the skin or eyes, dark urine, fatigue, or abdominal pain, to your provider immediately, as these can indicate serious liver problems.

• Drug Interactions: Be aware that certain medications can affect the absorption and effectiveness of ursodiol (Actigall). Bile acid sequestering agents, like cholestyramine and colestipol, and aluminum-based antacids, such as Maalox and Mylanta, may hinder its absorption. Additionally, estrogens, oral contraceptives, and some cholesterol-lowering drugs could reduce its efficacy. Consult your healthcare provider if you are taking any of these medications to manage potential risks effectively.

Ensure you follow these precautions and consult with your healthcare professional for any concerns or questions regarding the use of ursodiol (Actigall).

When taking this medication, some individuals may experience common side effects such as headache, dizziness, diarrhea, constipation, upset stomach, stomach pain, and nausea. These effects are usually mild, but if they persist or worsen, it is advisable to consult with your healthcare provider.

Other side effects that have been reported include skin rash, vomiting, bladder infection, muscle pain, cough, sore throat, sinus infection, and hair thinning. While these are generally not severe, seeking medical advice if they occur can be beneficial.

There are also rare but serious side effects that necessitate immediate medical attention. These include severe allergic reactions characterized by hives, difficulty breathing, or swelling of the face, lips, tongue, or throat; jaundice, which presents as yellowing of the skin or eyes; dark urine; clay-colored stools; and severe abdominal pain.

Additionally, if you experience symptoms such as weakness, swelling of the ankles or feet, increased thirst or urination, signs of infection like a persistent sore throat or fever, easy bruising or bleeding, or symptoms suggesting a stomach or intestinal blockage such as abdominal pain, loss of appetite, cramping, or vomiting, it is crucial to contact your healthcare provider promptly.

Remember, while many individuals may not experience serious side effects, staying informed and vigilant about any changes in your health is important for your well-being.