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It is essential to be aware of the safety information related to the use of ursodiol (Actigall). Below are important considerations that should be taken into account. If you have any questions or concerns, consult your healthcare provider.

• Liver Function Monitoring: While ursodiol (Actigall) does not typically cause liver damage, your healthcare provider will conduct liver function tests before and during your treatment to ensure proper liver function. Contact your healthcare provider immediately if you experience symptoms such as yellowing of the skin or eyes, dark urine, fatigue, or stomach pain, as these may indicate serious liver issues.

• Drug Interactions: Certain medications can interfere with the absorption and effectiveness of ursodiol (Actigall). These include:

  • Bile acid sequestering agents such as cholestyramine and colestipol.
  • Aluminum-based antacids like Maalox and Mylanta.
  • Estrogens and oral contraceptives.
  • Some cholesterol-lowering medications. It is important to inform your healthcare provider about all medications you are taking to avoid any potential interactions.

There are no specific contraindications noted for ursodiol (Actigall); however, always discuss with your healthcare provider to ensure it is safe for your particular health situation.

Common side effects:

• Stomach upset
• Nausea
• Diarrhea
• Dizziness
• Headaches
• Constipation
• Stomach pain
• Back pain
• Hair thinning

Less common but important to monitor:

• Skin rashes
• Vomiting
• Bladder infections
• Muscle pain
• Cough
• Sore throat
• Sinus infections

Serious side effects:

• Severe allergic reactions
• Jaundice
• Dark urine
• Clay-colored stools
• Severe abdominal pain
• Signs of infection

When taking ursodiol, it's important to be aware of potential interactions with other medications that can affect its effectiveness. Here are some key considerations:

Bile Acid Sequestrants: Medications like Cholestyramine and Colestipol are used to lower cholesterol levels by binding bile acids in the intestine. However, they can also bind to ursodiol, reducing its absorption and effectiveness. To minimize this interaction, it's recommended to take ursodiol at least one hour before or four to six hours after these medications.

Aluminum-Based Antacids: Antacids containing aluminum, such as certain formulations of Maalox or Mylanta, can bind to bile acids, including ursodiol, in the digestive tract. This binding can decrease the absorption of ursodiol. To avoid this, take ursodiol at least one hour before or two hours after consuming aluminum-based antacids.

Medications Affecting Lipid Metabolism: Drugs that influence lipid metabolism, such as estrogens (including those in oral contraceptives) and certain lipid-lowering agents like clofibrate, can increase cholesterol secretion in the liver. This increase may promote gallstone formation and potentially counteract the therapeutic effects of ursodiol. If you're using these medications, discuss with your healthcare provider how they might impact your ursodiol treatment.

Other Considerations: While not as well-documented, some reports suggest that medications like Ciprofloxacin, a type of antibiotic, may have reduced effectiveness when taken with ursodiol. The exact mechanism isn't fully understood, so it's advisable to consult your healthcare provider if you're prescribed both medications.

Always inform your healthcare provider about all the medications and supplements you're taking to ensure they can manage potential interactions effectively.