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Veegum, known chemically as magnesium aluminum silicate, is a naturally occurring mineral widely used in pharmaceuticals and cosmetics for its properties as a thickener, stabilizer, and binder. While generally considered safe for topical and oral applications, certain precautions are advisable.

In animal studies, high oral doses of magnesium aluminum silicate have been associated with mild skin irritation and, at very high dietary levels, slightly stunted growth in rats. However, these effects were observed at doses significantly higher than those typically used in human applications.

When formulating products, it's important to note that magnesium aluminum silicate can interact with certain cationic compounds, such as quaternary ammonium compounds used in hair conditioners, potentially leading to product instability. Therefore, careful formulation is necessary to ensure product efficacy and safety.

Overall, Veegum is considered safe for use in various applications when used appropriately. As with any ingredient, it's important to follow recommended usage levels and consult with a healthcare professional if you have specific concerns.

Veegum®, a refined form of magnesium aluminum silicate, is widely used in pharmaceutical formulations for its properties as a suspending agent, emulsifier, and viscosity enhancer. Generally, Veegum® is considered inert and compatible with a broad range of active pharmaceutical ingredients (APIs) and excipients.

However, certain interactions can influence the performance of Veegum® in formulations. For instance, the addition of non-ionic surfactants like Tween 80 and Brij 98 to Veegum® suspensions has been observed to increase both the plastic viscosity and yield stress of the mixture. These surfactants can also alter the thixotropic behavior of the suspension, with the extent of these changes depending on the surfactant concentration and the equilibration time between the surfactant and Veegum®.

Additionally, the sequence and method of incorporating excipients can affect the stability of Veegum®-based suspensions. For example, abrupt pH adjustments using concentrated Citric Acid solutions have been linked to flocculation and phase separation issues in some formulations. To mitigate such problems, it is advisable to adjust the pH gradually and ensure thorough mixing to maintain suspension stability.

While Veegum® is compatible with many substances, careful consideration of formulation components and processing methods is essential to preserve the desired properties of the final product.