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This safety information highlights important warnings related to the use of Viberzi (eluxadoline). Please read it carefully and consult your healthcare provider if you have any questions or concerns.

• Pancreatitis Risk: Viberzi (eluxadoline) has been associated with cases of pancreatitis, a serious condition involving inflammation of the pancreas. This risk is particularly elevated in individuals without a gallbladder and those consuming more than three alcoholic beverages daily. Symptoms typically appear within the first week of treatment and include severe abdominal pain that may radiate to the back or shoulders, possibly accompanied by nausea and vomiting. If you experience these symptoms, discontinue the medication immediately and seek medical advice.

• Constipation: Use of Viberzi (eluxadoline) may lead to constipation, which in some instances can result in significant complications necessitating medical intervention. Should you experience constipation while on this medication, stop using it and contact your healthcare provider.

• Allergic Reactions: There is a potential for allergic reactions in some individuals taking Viberzi (eluxadoline), which may occur shortly after the initial doses. Symptoms can include difficulty breathing, facial or throat swelling, and chest pain or tightness. If you experience any of these symptoms, discontinue use immediately and contact your healthcare provider.

Please note that there are no specific contraindications listed for Viberzi (eluxadoline) in the provided information. Always seek guidance from your healthcare provider before making any changes to your medication regimen.

When taking this medication, some individuals may experience mild side effects such as constipation, nausea, or abdominal pain. These effects are generally not severe, but if they persist or worsen, please consult your healthcare provider for advice. Other less common side effects include symptoms similar to a common cold (such as a runny nose and cough), vomiting, bloating, dizziness, gas, and rash.

While most side effects are not serious, there are rare instances of severe reactions. These include signs of pancreatitis, characterized by severe abdominal pain that may radiate to the back or shoulder, which requires immediate medical attention. Additionally, a very serious allergic reaction to this drug is rare but possible. If you experience symptoms such as a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing, seek emergency medical help immediately.

It is important to note that many people taking this medication do not experience severe side effects. However, always remain vigilant and contact your healthcare provider if you notice any concerning symptoms. Remember that the list above is not exhaustive, and any unexpected effects should be discussed with a healthcare professional.