Xywav

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Xywav is a medication primarily used to manage narcolepsy, a condition characterized by excessive daytime sleepiness and sudden muscle weakness known as cataplexy. It is also approved for the treatment of idiopathic hypersomnia (IH) in adults. Xywav contains a combination of calcium, magnesium, potassium, and sodium oxybates and functions as a central nervous system depressant. While the precise mechanism is not fully understood, it is believed to increase the activity of gamma-aminobutyric acid (GABA) in brain areas responsible for regulating sleep and wakefulness. The medication is typically administered orally in liquid form, twice nightly for narcolepsy, with some individuals with IH taking it once per night. Potential side effects include headache, nausea, and dizziness. Always consult a healthcare professional before starting any new treatment.
Our Xywav coupons are free to use. You can print the coupon, email it to yourself, or receive the Xywav coupon via text message. To get your free discount, show the pharmacist your Xywav savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Xywav prices will update based on your prescription needs. Above our Xywav coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Xywav savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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180ML of 500MG/ML, Xywav (1 Bottle)

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Rite Aid

$6554.65

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Rite Aid

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Xywav dosage forms

The average cost for 1 Bottle of Xywav at 180ML of 500MG/ML is $6644.47 with a free coupon. This is 27.95% off the average retail price of $23773.08
DosageQuantityPrice fromPer unit
180ML of 500MG/ML1 Bottle$6644.47$6644.47

Xywav Warnings

This medication is a potent central nervous system (CNS) depressant and carries a significant risk of misuse. It is essential to use this drug strictly as prescribed by your healthcare provider. Misuse or abuse can lead to severe health consequences, including seizures, difficulty breathing, loss of consciousness, and potentially fatal outcomes. The following points summarize critical safety and warning information for this medication:

  • Breathing and Alertness Risks: This medication can significantly slow down your breathing and cause severe drowsiness, even at prescribed doses. Avoid using it with alcohol or other CNS depressants, as this may exacerbate these effects. Individuals with breathing issues, such as COPD, asthma, or sleep apnea, should consult their healthcare provider before use.

  • Misuse and Dependency Risks: As a Schedule III controlled substance, this medication has a potential for misuse, which can lead to life-threatening side effects such as seizures, coma, and death. A personal or family history of substance or alcohol use disorder increases this risk. Misuse can also result in addiction.

  • Regulatory Compliance: In the United States, this medication is accessible only through the REMS Program, which requires participation from you, your prescriber, and your pharmacy to ensure safe use. Consult your healthcare provider about regulations specific to your country if you reside outside the U.S.

  • Withdrawal Symptoms: Abruptly stopping the medication may lead to withdrawal symptoms such as anxiety, insomnia, hallucinations, nausea, and muscle aches. These symptoms can occur even at recommended doses, especially with long-term use. It is crucial to discuss with your prescriber how to safely discontinue or adjust your dosage.

  • Mental Health Concerns: Some individuals may experience depression, suicidal thoughts, or other mental health issues while taking this medication. If you encounter any unusual mental health symptoms, contact your healthcare provider immediately. Seek urgent medical help if you have thoughts of self-harm.

  • Unusual Sleep Behaviors: The medication may cause sleepwalking or other parasomnias, increasing the risk of injury. Inform your healthcare provider if you experience such episodes and ensure your family is aware of these risks.

  • Contraindications: Do not use this medication if you are taking other sedative hypnotics, consuming alcohol, or have a rare condition called succinic semialdehyde dehydrogenase deficiency. Always consult your healthcare provider if you have any concerns or questions about these contraindications.

In case of an overdose, seek emergency medical attention immediately. Always follow your healthcare provider’s instructions and report any side effects or concerns promptly.

Xywav Side Effects

When taking this medication, you might encounter some common side effects that are typically mild. These include nausea, headache, anxiety, dizziness, difficulty sleeping, increased sweating, and reduced appetite. While these symptoms are often not serious, it's important to inform your healthcare provider if they persist or worsen.

In addition to these common side effects, some individuals may experience bed-wetting, vomiting, tiredness, or diarrhea. Again, if these symptoms continue or become more severe, consulting your healthcare provider is advisable.

There are also some rare but serious side effects that require immediate medical attention. These include mental or mood changes such as confusion, hallucinations, agitation, depression, or thoughts of suicide. Other concerning symptoms include numbness or tingling of the skin, shaking, or sleepwalking. Furthermore, difficulty breathing, especially during sleep, is a serious concern and should be addressed urgently.

Lastly, although very rare, some people may experience a severe allergic reaction to this medication. Symptoms such as rash, itching or swelling, severe dizziness, or trouble breathing necessitate urgent medical care. If you notice any side effects not listed here, it's important to contact your healthcare provider for advice.

Xywav Interactions

Combining this medication with other substances that cause drowsiness or breathing difficulties can raise the likelihood of severe side effects like slow or shallow breathing and significant drowsiness or dizziness. It's important to inform your doctor or pharmacist if you are taking any other products, including opioid painkillers or cough suppressants (like codeine or hydrocodone), alcohol, cannabis, sleep or anxiety medications (such as alprazolam, lorazepam, or zolpidem), muscle relaxants (such as carisoprodol or cyclobenzaprine), or antihistamines (like cetirizine or diphenhydramine). Additionally, check the labels of all your medications, including those for allergies or cough-and-cold, as they might contain ingredients that cause drowsiness. Consult your pharmacist to ensure the safe use of these products.
Xywav FAQs
What does XYWAV do?

XYWAV is a medication used to treat cataplexy or excessive daytime sleepiness in patients with narcolepsy. It works by affecting certain neurotransmitters in the brain to help regulate sleep-wake cycles.

Yes, XYWAV is classified as a controlled substance. It is listed under Schedule III of the Controlled Substances Act in the United States.

XYWAV (calcium, magnesium, potassium, and sodium oxybates) is used to treat idiopathic hypersomnia by helping to improve wakefulness and reduce excessive daytime sleepiness. It works by modulating neurotransmitter activity in the brain, which can help regulate sleep-wake cycles and improve overall sleep quality. This can lead to increased alertness and better functioning during the day for individuals with idiopathic hypersomnia.

Xyrem and XYWAV are both medications used to treat narcolepsy, specifically for cataplexy and excessive daytime sleepiness. The primary difference between the two is their formulation. Xyrem contains sodium oxybate, while XYWAV is a lower-sodium formulation that includes a combination of calcium, magnesium, potassium, and sodium oxybates. This difference in formulation makes XYWAV a potentially better option for patients who need to manage their sodium intake.

The trade name for oxybate is Xyrem.