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The following safety information outlines important risks and precautions associated with the use of dextroamphetamine. It is crucial to fully understand these warnings and consult with your healthcare provider for any questions or concerns.

• Misuse and Dependence: Dextroamphetamine carries a risk of misuse and dependence. Misuse occurs when the medication is used in a manner not prescribed, leading to severe and potentially life-threatening side effects, such as increased heart rate, high blood pressure, heart issues, and behavioral changes. Over time, reliance on dextroamphetamine can develop, resulting in withdrawal symptoms like irritability, nightmares, and sleep disruptions if the medication is abruptly discontinued after long-term use. Adherence to prescribed dosages and frequency is essential. Risk factors include a history of substance or alcohol use disorder, excessive dosing, prolonged use, and sudden cessation.

• Serious Heart-Related Issues: There is a risk of sudden death, stroke, and heart attack in individuals with pre-existing heart conditions taking dextroamphetamine, even at standard doses. The medication can elevate blood pressure and heart rate. It's vital to inform your healthcare provider about any heart-related history before starting treatment. Contact your provider immediately if you experience unexplained fainting, chest pain during physical activity, or irregular heartbeat. Risk factors include a history of heart problems.

• Aggressive Behavior and Psychosis: Some users may experience mental health issues such as hallucinations, aggressive conduct, unclear thinking, and mania. These symptoms can occur even without a prior history of such problems and may worsen existing mood disorders. If you notice these symptoms, consult your healthcare provider promptly, as discontinuation may be necessary. Risk considerations include a history of psychotic episodes, bipolar disorder, or other mood disorders.

• Slowed Growth in Children: There is evidence suggesting that stimulant medications for ADHD may slow growth in children. While not definitively linked to dextroamphetamine, healthcare providers will monitor growth progress closely and may adjust treatment if necessary. Discuss any concerns with your child's provider.

• Seizures: Though rare, dextroamphetamine can increase seizure risk, particularly in individuals with a history of seizures. Immediate medical attention is required if a seizure occurs while on this medication. Risk factors include a history of seizures or high seizure risk.

• Blood Circulation Problems: Dextroamphetamine may be associated with blood circulation issues, such as Raynaud's phenomenon, causing fingers and toes to feel cold, numb, or painful. These symptoms typically improve with dose adjustment or cessation. Notify your healthcare provider if these issues arise.

• Serotonin Syndrome: This potentially life-threatening condition is characterized by excessive serotonin in the brain. Dextroamphetamine may increase serotonin levels, especially when combined with other serotonin-altering medications (e.g., certain antidepressants, MAOIs, migraine medications). Symptoms include fast heart rate, sweating, muscle stiffness, fever, behavioral changes, and confusion. Seek immediate medical assistance if these occur. Risk factors include using MAOIs within 14 days before starting dextroamphetamine or taking other serotonin-increasing drugs.

• Medication Interactions: Dextroamphetamine can interact with numerous medications, particularly counteracting the effects of some blood pressure treatments like prazosin and beta-blockers. This may reduce the effectiveness of these medications.

Contraindications: Avoid using dextroamphetamine if you have:

• A severe allergy to amphetamine-containing products.
• Heart or blood vessel problems, such as moderate-to-severe hypertension, heart disease, or atherosclerosis.
• Overactive thyroid (hyperthyroidism).
• Glaucoma.
• Feelings of agitation or distress.
• A history of substance use disorder.
• Recent or current use of MAOIs within the past 14 days.

Always consult your healthcare provider to ensure this medication is safe for you based on your medical history and current health status.

Common side effects:

• Nausea
• Stomach upset
• Cramps
• Loss of appetite
• Diarrhea
• Dry mouth
• Headache
• Nervousness
• Dizziness
• Trouble sleeping
• Sweating
• Weight loss
• Irritability
• Restlessness
• Fast heartbeats
• Tremors

Less common but important to monitor:

• Constipation
• Hives
• Changes in sex drive
• Blurry vision

Serious side effects:

• Symptoms of blood flow issues in fingers or toes
• Significant mental/mood changes
• Uncontrolled movements
• Muscle twitching or shaking
• Frequent or prolonged erections in males
• Shortness of breath
• Chest pain
• Fast/pounding heartbeat
• Raised blood pressure
• Serotonin syndrome
• Very serious allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)
• Amphetamine
• Lisdexamfetamine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Antidepressants (SSRIs such as Fluoxetine, paroxetine, SNRIs such as Duloxetine, Venlafaxine)
• Street drugs (MDMA/"ecstasy")
• St. John's wort

Interactions with low risk that usually do not require a change in therapy:

• Cough-and-cold products or diet aids