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The use of certain medications, especially hormonal contraceptives like Yasmin, requires careful consideration of several health factors due to potential risks and interactions. Below is an outline of critical safety information and warnings that should be reviewed carefully. If you have any questions or concerns, please consult your healthcare provider.

• Smoking and Heart Health Risks: Women over 35 who smoke should not use Yasmin, as smoking increases the risk of serious cardiovascular events, such as strokes, heart attacks, and blood clots.

• Risk of Blood Clots and Stroke: Yasmin can increase the likelihood of blood clots, which can occur in the lungs, legs, brain, or heart. Seek immediate medical attention if you experience symptoms of a blood clot. Factors increasing this risk include smoking, age above 35, recent surgery, high blood pressure, obesity, diabetes, and high estrogen doses.

• Cancer Risk: There is a potential but uncertain link between the use of Yasmin and an increased risk of breast and cervical cancer, especially with long-term use or a personal history of these cancers.

• Liver Concerns: Although rare, Yasmin may contribute to liver damage or tumors, especially when higher doses of estrogen are involved. Avoid using Yasmin if you have existing liver issues, and contact your provider if you notice signs of liver problems, such as fatigue or jaundice.

• High Blood Pressure: Yasmin may elevate blood pressure. Regular monitoring is advised, and if blood pressure becomes too high, alternative birth control methods should be considered.

• Blood Sugar and Lipid Levels: Yasmin might affect blood sugar and lipid levels, potentially worsening conditions like diabetes. Regular check-ups are essential to monitor these changes.

• Headaches and Migraines: While headaches are a common side effect, new or worsening migraines should be evaluated by a healthcare professional.

• Depression: Report any new or worsening symptoms of depression to your provider. In severe cases, discontinuation of Yasmin may be necessary.

• Drug Interactions: Certain medications can alter the effectiveness of Yasmin or increase side effects. It is crucial to inform your healthcare provider of all medications you are taking.

• High Potassium Levels: Yasmin may cause elevated potassium levels, particularly when combined with other medications that increase potassium. Monitoring is recommended for those with kidney, liver, or adrenal issues.

Contraindications: Do not use Yasmin if you have any of the following conditions, as they may lead to serious health risks:

• Kidney, liver, or adrenal problems
• Women over 35 who smoke
• High risk of blood clots or vascular issues
• Unexplained uterine bleeding
• Certain heart conditions
• Uncontrolled high blood pressure or diabetes
• Pregnancy
• Current or past hormone-sensitive breast cancer
• Severe headaches or migraines, especially after age 35
• Liver tumors
• Current treatment with Viekira Pak

It is essential to consult with a healthcare provider before starting Yasmin to ensure it is appropriate for your health profile.

When using this medication, some common side effects may occur, usually mild and manageable. These include nausea, vomiting, headaches, bloating, and breast tenderness. Additionally, some patients may experience swelling of the ankles and feet due to fluid retention, as well as weight changes. Vaginal bleeding between periods, known as spotting, or missed and irregular periods can also happen, especially in the initial months of use. If these effects persist or worsen, it is advisable to consult your healthcare provider.

The medication may also lead to increased blood pressure, so regular monitoring is recommended. Mood changes, including depression, are possible and should be discussed with your doctor if they arise. In rare cases, serious side effects can occur, necessitating immediate medical attention. These include unusual changes in vaginal bleeding, symptoms of high blood potassium levels like muscle weakness and irregular heartbeat, as well as signs of blood clots such as chest pain, difficulty breathing, severe headaches, and sudden dizziness.

Very serious side effects, though uncommon, include lumps in the breast, severe abdominal pain, dark urine, yellowing of the skin or eyes, and significant mental/mood changes. Allergic reactions are rare but require urgent medical care if symptoms like rash, swelling, severe dizziness, or trouble breathing occur. While this is not an exhaustive list of potential side effects, it is important to stay informed and contact your healthcare provider with any concerns.

When using this medication, it's important to be aware of potential interactions with other drugs. Some medications, such as aromatase inhibitors (like anastrozole and exemestane), atazanavir, cobicistat, fezolinetant, fosamprenavir, ospemifene, tamoxifen, tizanidine, and tranexamic acid, may interact with this drug. These interactions can alter how the drug works or increase side effects.

Additionally, this medication can raise potassium levels in your blood. If you are taking other medicines that also elevate potassium levels, such as aliskiren, ACE inhibitors (like enalapril and lisinopril), angiotensin receptor blockers (such as losartan and valsartan), heparin, NSAIDs (such as ibuprofen and naproxen), or potassium-sparing diuretics (like eplerenone, spironolactone, and triamterene), it's important to inform your doctor.

Certain medications can reduce the effectiveness of hormonal birth control, potentially leading to unintended pregnancy. This includes drugs like griseofulvin, modafinil, rifamycins (such as rifampin), certain seizure medications (like carbamazepine and phenytoin), some HIV drugs (like nelfinavir and nevirapine), and herbal supplements such as St. John's wort. It’s advisable to discuss with your doctor whether you should use additional birth control methods and report any unexpected bleeding, as this might indicate reduced contraceptive efficacy.

Lastly, this medication may affect lab test results. Make sure to inform all healthcare providers and lab personnel that you are using this medication to avoid any misinterpretation of test outcomes.