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The following information outlines important safety warnings for the use of Ziana (clindamycin/tretinoin). It is crucial to understand the potential risks and precautions associated with this medication. If you have any questions or concerns, please consult with your healthcare provider.

• Severe Diarrhea: Ziana, like other antibiotics, can cause diarrhea by disrupting the balance of beneficial bacteria in the gut. Although this risk is lower with topical treatments compared to oral antibiotics, it is important to be aware. In rare instances, the diarrhea may be due to an infection with Clostridioides difficile (C. diff), which is a highly contagious bacterium that can lead to severe dehydration. If you suspect a C. diff infection, practice good hygiene by washing hands with soap for at least 20 seconds and use separate bathroom facilities from others until symptoms resolve. Consider taking probiotics to help mitigate this risk. Individuals with pre-existing bowel conditions such as Crohn's disease or ulcerative colitis, or those who have previously experienced severe diarrhea from antibiotics, should inform their healthcare provider, as they are at an increased risk.

• Sun Sensitivity: Usage of Ziana may make your skin more susceptible to sunburn. It is advisable to limit sun exposure, apply sunscreen with a minimum SPF of 30, and wear protective clothing such as wide-brimmed hats whenever outdoors, regardless of the season or weather.

Please note that there are no specific contraindications listed for this medication. Always consult your healthcare professional for personalized advice and guidance.

When using this medication, some individuals may experience common side effects such as skin redness, dryness, itching, peeling, and a mild burning or stinging sensation. These effects are generally mild and often decrease with continued use, typically observed within the first 2 to 4 weeks. Using a daytime moisturizer can help alleviate very dry skin. However, if these symptoms persist or worsen, it is important to consult with a healthcare provider.

In certain cases, users may notice scaly skin, flu-like symptoms, or a burning sensation. While these are less common, they still warrant attention if they become bothersome. Most people using this medication do not encounter serious side effects, but it is crucial to be aware of potential severe reactions.

Rare, yet significant, side effects include blistering or crusting of the skin, severe burning, or swelling. Additionally, the medication may rarely lead to a serious intestinal condition caused by C. difficile, characterized by persistent diarrhea, abdominal pain, or blood/mucus in the stool. In such instances, avoid using anti-diarrhea or opioid products as they might exacerbate symptoms. Immediate medical attention is necessary for any signs of a serious allergic reaction, such as rash, swelling, severe dizziness, or difficulty breathing.

While these are not all possible side effects, it is important to seek medical advice if you notice any unusual symptoms. Always reach out to a healthcare professional if you have concerns or questions about the side effects of this medication.