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This medication carries important safety information about potential risks and precautions you should be aware of. It is crucial to read these points carefully and consult with your healthcare provider if you have any questions or concerns.

• Severe Diarrhea: The clindamycin component in Ziana (clindamycin/tretinoin) may cause diarrhea as it can disrupt the balance of beneficial bacteria in the gut. Although this is less common with topical applications compared to oral antibiotics, it can occur. In rare instances, diarrhea may be triggered by Clostridioides difficile (C. diff), a harmful bacterium typically controlled by healthy gut bacteria. C. diff-related diarrhea is highly contagious and can result in severe dehydration. If diagnosed with C. diff, ensure that you practice good hygiene by washing your hands thoroughly with soap for at least 20 seconds and, if possible, use a separate bathroom from others until recovery. Taking probiotic supplements during treatment with Ziana may help mitigate this risk. Individuals with inflammatory bowel diseases such as Crohn's disease or ulcerative colitis, or those who have previously experienced severe diarrhea from antibiotics, are at increased risk. Inform your healthcare provider if you have these conditions.

• Sun Sensitivity: Ziana (clindamycin/tretinoin) may increase your skin's sensitivity to sunlight, making it more prone to sunburn. Minimize sun exposure and apply a sunscreen with a minimum SPF of 30. Additionally, wear protective clothing such as wide-brimmed hats when outdoors, regardless of the weather conditions, including winter or cloudy days.

Please discuss any medical history of bowel issues or previous adverse reactions to antibiotics with your healthcare provider to ensure safe use of this medication.

When using this medication, some common side effects you might experience include skin redness, dryness, itching, peeling, and a mild burning or stinging sensation. These effects are usually temporary, often occurring in the first 2 to 4 weeks, and tend to improve with continued use. If you have very dry skin, a daytime moisturizer can help. If these side effects persist or worsen, it's important to consult your healthcare provider.

In some cases, the medication may lead to more serious side effects. These include blistering or crusting of the skin, severe burning or swelling, and a rare but serious intestinal condition caused by C. difficile bacteria. This condition can manifest as persistent diarrhea, abdominal pain, and blood or mucus in your stool, and it may occur during or even weeks to months after treatment. If you experience these symptoms, avoid using anti-diarrhea or opioid products and seek medical help promptly.

Though very rare, allergic reactions can occur, with symptoms like rash, severe dizziness, swelling, or trouble breathing. If you notice any signs of an allergic reaction, seek emergency medical attention immediately. Always report any other unexpected side effects to your healthcare provider for further advice.

When treating an area with this medication, avoid applying other skin products that may cause irritation, dryness, or harsh effects. Such products include hair perming solutions and those containing alcohol, lime, or menthol, like astringents, toners, or shaving lotions. Also, steer clear of medicated or abrasive soaps, cleansers, and cosmetics that have a strong drying effect, such as those with alpha hydroxy acids or glycolic acid. Additionally, do not use products containing sulfur, resorcinol, or salicylic acid on the treated area.

Benzoyl peroxide, in particular, can cause significant irritation and may reduce the effectiveness of this medication if used simultaneously. It is important to consult with your doctor or pharmacist on how to safely use both prescription and over-the-counter benzoyl peroxide products.