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This document provides critical safety information regarding the use of Zilxi (minocycline topical foam). It's essential to review these warnings and consult your healthcare provider with any concerns.

• Fire Risk: Zilxi contains a propellant that is highly flammable. Handle the foam carefully during and after application to prevent fire hazards. Avoid smoking or going near open flames immediately after applying the medication. Store the can away from extreme heat and temperatures above 120°F, and do not puncture or expose it to open flames.

• Antibiotic-Resistant Bacteria: Use Zilxi strictly as prescribed for treating rosacea. Although it contains minocycline, Zilxi is not approved for treating infections. Misuse can contribute to the development of antibiotic-resistant bacteria, which are challenging to treat.

• Risk of New Infections: Misusing Zilxi, like other antibiotics, can cause an overgrowth of non-target bacteria or fungi, leading to new infections such as skin yeast infections. Do not use this medication longer than prescribed and report any symptoms like itching, burning, or rash to your healthcare provider.

• Sunburn and Skin Side Effects: Users of oral tetracycline antibiotics, including minocycline, have reported increased susceptibility to sunburn and changes in skin pigmentation. Exercise caution when exposed to sunlight.

• Bone Growth in Children: While oral tetracycline antibiotics can impede bone growth in children, which typically resumes after stopping the medication, it is unknown if Zilxi has the same effect. Zilxi is only approved for use in adults.

• Rare Risks from Oral Minocycline: Oral tetracycline antibiotics may cause severe side effects like infectious diarrhea, liver issues, and nervous system problems. Although these have not been observed with Zilxi use, consult your healthcare provider about potential side effects.

No specific contraindications are identified for Zilxi (minocycline topical foam).

When using this medication, some common side effects may occur, though they are generally mild and manageable. You may experience spider veins on the face, redness or warmth in the skin, dry skin, darkening around the application site, and itching. If these effects persist or worsen, it's advisable to consult a healthcare provider for guidance.

In addition to these, some users report skin peeling, burning or stinging sensations, and diarrhea. While these are less common, it's important to monitor any such reactions and seek advice if they become severe.

There are serious side effects associated with this medication that require immediate medical attention, though they are rare. Be alert for symptoms such as allergic reactions characterized by skin rash, itching, hives, or swelling of the face, lips, tongue, or throat. Other concerning signs include rash, fever, swollen lymph nodes, and redness, blistering, peeling, or loosening of the skin, including in the mouth.

Furthermore, this medication may rarely cause a severe intestinal condition due to C. difficile bacteria, leading to persistent diarrhea, abdominal pain, or blood/mucus in stools. It may also rarely result in increased pressure around the brain, particularly in women of childbearing age who are overweight, leading to severe headaches, vision changes, or persistent nausea. If any of these symptoms occur, immediate medical attention is necessary to prevent complications.