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The information below outlines crucial safety warnings associated with the use of Zoladex (goserelin). It is important to read these warnings thoroughly and discuss any concerns with your healthcare provider.

• Risk to Unborn Children: Zoladex (goserelin) may harm an unborn baby. Women of childbearing age or those who have not yet experienced menopause must have a negative pregnancy test before starting treatment. Non-hormonal birth control methods, such as condoms, diaphragms, or intrauterine devices (IUDs), should be used during and for 12 weeks after completing treatment, as hormonal contraceptives may be less effective. Consult your healthcare provider to determine the most suitable non-hormonal birth control option. If pregnancy is planned, discuss this with your provider before beginning Zoladex (goserelin).

• Tumor-Flare Syndrome: For those using Zoladex (goserelin) for prostate or breast cancer, there is a potential for tumor-flare syndrome, which may cause an increase in bone pain or tissue inflammation around the tumor during initial treatment weeks. This may result in a temporary worsening of symptoms. Report any bone pain, difficulty urinating, weakness, or worsening symptoms to your healthcare provider, who may offer treatments to manage these effects.

• Elevated Blood Sugar Levels: Zoladex (goserelin) can increase blood sugar levels, potentially leading to new or worsening diabetes, especially in individuals with diabetes or pre-diabetes. Your healthcare provider may recommend regular blood sugar monitoring while taking this medication.

• Cardiovascular Concerns: GnRH agonists, including Zoladex (goserelin), can heighten the risk of heart attack, stroke, or heart-related death, particularly in men. Seek immediate medical attention if you experience symptoms such as chest or arm pain, cold sweat, confusion, facial droop, weakness on one side, shortness of breath, or difficulty walking or speaking. This is especially important for those with a history of heart issues or who are taking medications for heart rhythm control, such as antidepressants or antibiotics.

• Injection Site Reactions: Injuries may occur at the injection site. Notify your provider if you experience swelling, bruising, or bleeding around the stomach area, or if you have shortness of breath, dizziness, or faintness. This risk is higher for individuals with a low body mass index (BMI).

• Severe Allergic Reactions: There is a risk of serious allergic reactions with Zoladex (goserelin). Contact your healthcare provider immediately if you have breathing difficulties, hives, or swelling in the tongue, lips, neck, or face.

It is imperative to adhere to these guidelines and consult with your healthcare provider for any questions or concerns regarding Zoladex (goserelin) usage.

When taking this medication, you may encounter some common side effects, which are generally mild and should not cause alarm. These include hot flashes, affecting nearly half of users, diarrhea, experienced by 40%, nausea, and skin rash. If these symptoms persist or become bothersome, it's advisable to discuss them with your healthcare provider.

Some users might experience other side effects, which vary in severity. These include sexual dysfunction, body or breast pain, headache, dizziness, edema or swelling, difficulty urinating, and urinary tract infections. While these are not typically dangerous, you should seek medical advice if they become severe or troublesome.

It's important to be aware of rare but serious side effects that necessitate immediate medical attention. These include allergic reactions, heart attack symptoms like chest pain and shortness of breath, stroke indicators such as confusion and facial drooping, and QT prolongation syndrome, which may cause palpitations. Additionally, signs of shock, including a racing heart, fever, and faintness, require urgent care. Always prioritize your health and seek prompt medical attention if you suspect any of these severe reactions.