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This drug safety guide outlines crucial information about the potential risks and necessary precautions when using Leuprolide (Lupron Depot). Please review the following points carefully, and consult your healthcare provider if you have any concerns.

• Bone Health Risk: Leuprolide (Lupron Depot) can reduce estrogen levels, leading to bone weakening and potential bone loss. This condition may not be reversible after cessation of treatment. The risk is increased if you consume alcohol or tobacco, have a family history of osteoporosis, or take medications that lower bone density, such as antiseizure drugs or corticosteroids. Your healthcare provider will aim to limit your treatment duration to minimize this risk and may monitor your bone density or prescribe additional medications if needed.

• Pregnancy Warning: Animal studies suggest that Leuprolide (Lupron Depot) can harm unborn babies. It is crucial to avoid this medication during pregnancy. Your healthcare provider might request a pregnancy test before starting treatment. Use non-hormonal birth control methods, like condoms or a copper intrauterine device, while on this medication. Notify your provider immediately if you become pregnant during treatment.

• Allergic Reactions: Although rare, allergic reactions, including severe ones like anaphylaxis, can occur. Inform your provider about any allergies you have. Seek immediate medical attention if you develop a rash, difficulty breathing, or swelling in the face, mouth, or throat.

• Seizure Risk: In rare instances, seizures may occur in those taking Leuprolide (Lupron Depot). If you experience symptoms such as uncontrollable movements, confusion, or loss of consciousness, obtain medical help promptly.

• Depression Risk: There is a possibility of new or worsening depression when using Leuprolide (Lupron Depot). If you have a history of depression, notify your provider. Should you notice any new or aggravated symptoms, contact your provider to discuss whether it is safe to continue the medication or if other management strategies are needed.

Contraindications:

• Avoid using Leuprolide (Lupron Depot) if you have unexplained vaginal bleeding or are currently pregnant, as it may pose significant health risks. Consult your healthcare provider under these circumstances.

Common side effects:

• Hot flashes or sweating
• Headaches
• Vaginal inflammation
• Depression
• Pain
• Weight changes
• Nausea or vomiting
• Lower sex drive
• Dizziness
• Acne
• Skin reactions
• Mild burning or pain at the injection site
• Night sweats
• Tiredness
• Upset stomach
• Breast changes
• Joint or muscle aches
• Trouble sleeping
• Vaginal discomfort or dryness
• Vaginal bleeding
• Swelling of the ankles or feet
• Increased urination at night

Serious side effects:

• New or worsening bone pain
• Easily broken bones
• Increased thirst or urination
• Mental or mood changes
• Serious liver disease symptoms
• Heart problems
• Stroke
• Fast or irregular heartbeat
• Severe dizziness
• Fainting
• Seizures
• Increased pressure around the brain in children
• Very serious allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• Bepridil
• Cisapride
• Dronedarone
• Mesoridazine
• Pimozide
• Piperaquine
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Amiodarone
• Amisulpride
• Aripiprazole Lauroxil
• Buprenorphine
• Buserelin
• Ceritinib
• Citalopram
• Clofazimine
• Degarelix
• Deslorelin
• Deutetrabenazine
• Donepezil
• Encorafenib
• Entrectinib
• Formoterol
• Fostemsavir
• Glasdegib
• Gonadorelin
• Goserelin
• Histrelin
• Hydroxychloroquine
• Hydroxyzine
• Inotuzumab Ozogamicin
• Ivosidenib
• Lefamulin
• Lenvatinib
• Lofexidine
• Macimorelin
• Methotrimeprazine
• Mirtazapine
• Moricizine
• Nafarelin
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Ozanimod
• Papaverine
• Pimavanserin
• Pitolisant
• Ponesimod
• Ribociclib
• Selpercatinib
• Sertraline
• Siponimod
• Sotalol
• Sulpiride
• Sunitinib
• Triclabendazole
• Triptorelin
• Vemurafenib
• Voclosporin
• Zotepine
• Zuclopenthixol