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This safety information outlines critical warnings and contraindications for the use of this medication. Please read the details carefully and consult your healthcare provider if you have any questions or concerns.

• Flammability Warning (Foam Only): The foam form of Zoryve (roflumilast) is highly flammable. To prevent fire hazards, keep the foam canister away from open flames, such as lit cigarettes, during and immediately after applying the medication to your skin.

• Contraindications: Do not use this medication if you have moderate-to-severe liver problems, as it may pose significant health risks. It is crucial to discuss your liver health with your healthcare provider before using this medication.

Please ensure you follow these guidelines for safe use of the medication and consult your healthcare provider for any concerns or further information.

When taking this medication, some individuals may experience mild side effects such as diarrhea, nausea, or headache. These symptoms are generally not severe and often resolve on their own. However, if they persist or worsen, it is advisable to consult your healthcare provider. Additionally, some people may notice pain at the site of application, which is also typically mild.

In rare cases, more serious side effects can occur that require prompt medical attention. These include trouble sleeping, signs of infection such as a persistent sore throat, fever, or chills, and nose or throat inflammation. If you encounter any of these symptoms, it is important to seek medical care immediately.

Although a very serious allergic reaction is uncommon, it is crucial to be vigilant for any signs such as rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. If you experience any of these, seek emergency medical assistance without delay. Always stay alert for any unusual symptoms and consult your healthcare provider if you have concerns.