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This medication comes with several important safety warnings and contraindications that you should be aware of. Please read the information below carefully and discuss any concerns with your healthcare provider.

• Not for Acute COPD Symptoms: Roflumilast (Daliresp) is not intended for relieving sudden worsening of COPD symptoms, such as during a flare-up. It is not a rescue medication. In such cases, you should use your prescribed rescue inhaler to help alleviate breathing difficulties.

• Mood and Behavioral Changes: There is an increased risk of mood or behavioral changes when taking Roflumilast (Daliresp), including insomnia, anxiety, and depression. In rare instances, some individuals may experience suicidal thoughts or behaviors. This risk is heightened if you have a history of mental health issues.

• Weight Loss: A common side effect of Roflumilast (Daliresp) is weight loss. Clinical studies have shown that some individuals may lose between 5% to 10% or more of their body weight after a year of treatment. Most people regain this weight after discontinuing the medication.

• Drug Interactions: Roflumilast (Daliresp) can interact with various other medications. Certain drugs, such as rifampin, carbamazepine (Tegretol), and phenytoin (Dilantin), may decrease its effectiveness by lowering the levels of Roflumilast in the body. Discuss any current medications with your healthcare provider to avoid interactions.

• Contraindications: This medication should not be used by individuals with moderate or severe liver problems due to potential health risks. If you have liver issues, consult your healthcare provider before starting this medication.

By keeping these points in mind, you can better understand the potential risks and necessary precautions when using Roflumilast (Daliresp). Always consult your healthcare provider for personalized advice and guidance.

When taking this medication, you might experience some common side effects such as diarrhea, weight loss, nausea, headache, or dizziness. These are generally mild, but be sure to monitor their duration and intensity. If they persist or worsen, it’s advisable to consult your healthcare provider. Additionally, you might notice other side effects including loss of appetite, upset stomach, back pain, runny nose, sinus inflammation, flu-like symptoms, muscle spasms, or anxiety. While these are typically not severe, they should be discussed with a healthcare professional if they become bothersome.

More serious side effects, though rare, include mental health changes such as depression, anxiety, or suicidal thoughts, as well as difficulty sleeping, tremors, or an irregular heartbeat. These symptoms require prompt medical attention. In extremely rare cases, a severe allergic reaction may occur, characterized by a rash, itching or swelling, severe dizziness, or trouble breathing. Should you experience any of these symptoms, seek medical help immediately.

It is important to regularly check your weight, as this medication can sometimes cause unusual or extreme weight loss. Always communicate any significant changes in your health to your healthcare provider to ensure safe and effective treatment. Remember, this summary does not cover all possible side effects, so it's crucial to stay informed and consult your healthcare provider if you notice any other unusual symptoms.