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Diphenhydramine, commonly known as Benadryl, is an over-the-counter antihistamine used to alleviate symptoms associated with allergies, hay fever, and the common cold, such as rashes, itching, watery eyes, sneezing, and runny nose. Additionally, it is effective in preventing and managing nausea, vomiting, and dizziness due to motion sickness. This medication can also serve as an occasional sleep aid for individuals 12 years and older due to its sedative properties. The primary function of Diphenhydramine is to block the effects of histamine, a natural substance in the body responsible for allergy symptoms like sneezing and itching. It also reduces symptoms like watery eyes and runny nose by inhibiting another natural substance, acetylcholine, in the body. However, it is important to note that cough-and-cold products containing Diphenhydramine have not been proven safe or effective for children under 6 years old, and long-acting forms are not recommended for those under 12. This medication does not cure or shorten the duration of the common cold and may pose serious side effects if not used correctly. Always follow dosage instructions carefully and consult a healthcare professional before use, especially when administering to children. Avoid using Diphenhydramine to induce sleep in children and do not combine it with other cough-and-cold medications that might contain similar ingredients. For alternative relief from cold symptoms, consider options like staying hydrated, using a humidifier, or applying saline nasal solutions.
Our Zzzquil coupons are free to use. You can print the coupon, email it to yourself, or receive the Zzzquil coupon via text message. To get your free discount, show the pharmacist your Zzzquil savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Zzzquil prices will update based on your prescription needs. Above our Zzzquil coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Zzzquil savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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25MG, Zzzquil (30 Capsules)

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CVS

$36.85

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$10.12

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$19.22

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$20.88

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Zzzquil dosage forms

The average cost for 30 Capsules of Zzzquil at 25MG is $9.64 with a free coupon. This is 30.56% off the average retail price of $31.54
DosageQuantityPrice fromPer unit
25MG30 Capsules$9.64$0.32

Zzzquil Warnings

This medication includes important safety warnings that should be carefully considered. Consult your healthcare provider if you have any concerns or questions.

  • Accidental Overdose: Be cautious not to use multiple products containing diphenhydramine, the active ingredient in Benadryl, simultaneously. An overdose may cause symptoms such as dry eyes or mouth, rapid heartbeat, difficulty urinating, fever, and constipation. More severe effects include confusion, seizures, low blood pressure, muscle spasms, hallucinations, and heart rhythm disturbances. Ensure that you are not taking other diphenhydramine-containing products concurrently.

  • Excessive Sleepiness: This medication can cause significant drowsiness, impacting concentration, thinking, and reaction times. This is especially concerning for older individuals (65 years and above) due to an increased risk of falls and prolonged drowsiness into the following day. The sedative effect can be intensified by alcohol or other drowsiness-inducing medications such as opioids, benzodiazepines, or sleep aids. Refrain from driving or operating heavy machinery until you know how this medication affects you.

  • Worsening of Certain Health Conditions: Prior to using diphenhydramine (Benadryl), discuss with your healthcare provider if you have any of the following conditions: glaucoma, enlarged prostate, breathing issues such as emphysema, or kidney problems. The use of this medication can exacerbate these conditions and may lead to serious side effects.

There are no specific contraindications listed for this medication. However, always consult with your healthcare provider to ensure safe use.

Zzzquil Side Effects

When taking this medication, some individuals may experience common side effects such as drowsiness, dizziness, headache, dry mouth, nose, and throat, constipation, and blurred vision. These effects are usually mild and may subside over time. However, if they persist or worsen, it's advisable to consult with a healthcare provider. Simple remedies like staying hydrated or using saliva substitutes can help alleviate dryness of the mouth.

There are other side effects that some people might encounter, including nausea, vomiting, loss of appetite, muscle weakness, nervousness, and hyperactivity, particularly in children. Additionally, difficulty urinating might also be experienced. If any of these symptoms occur, especially if they seem severe, contacting a healthcare provider is recommended.

Serious side effects, while rare, demand immediate medical attention. These include mental or mood changes such as restlessness or confusion, seizures, irregular heartbeat, and severe allergic reactions characterized by rash, itching, swelling, or trouble breathing. Sudden eye pain, changes in vision, or difficulty passing urine are also critical and require urgent care. Although these severe side effects are uncommon, being aware of them ensures prompt action should they arise. Always stay informed about your health and consult a healthcare provider if you notice any unusual symptoms.

Zzzquil Interactions

Certain products may interact with this medication. These include topical antihistamines like diphenhydramine cream, ointment, or spray. Inform your doctor or pharmacist if you are using other substances that can cause drowsiness. This includes opioid pain or cough medications (such as codeine or hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, chlorpheniramine). Be sure to review the labels on all your medications, including those for allergies or colds, as they may contain ingredients that cause drowsiness. Consult your pharmacist to ensure safe use of these products. Additionally, this medication may affect certain laboratory tests, such as allergy skin tests, leading to inaccurate results. It is important to inform lab personnel and all your healthcare providers that you are using this medication.
Zzzquil FAQs
Is ZzzQuil really just Benadryl?

ZzzQuil and Benadryl both contain diphenhydramine as their active ingredient, which is an antihistamine. However, ZzzQuil is marketed specifically as a sleep aid, while Benadryl is primarily used for allergy relief. Despite their different branding and intended uses, they share the same active component.

It is not recommended to take ZzzQuil every night for sleep. ZzzQuil contains diphenhydramine, an antihistamine that can cause tolerance and dependence if used regularly. Long-term use may also lead to side effects such as dry mouth, constipation, urinary retention, and confusion, especially in older adults. It is advisable to consult a healthcare provider for safer, long-term sleep solutions.

Yes, there is a difference between ZzzQuil and Benadryl. Both medications contain diphenhydramine as their active ingredient, which is an antihistamine. However, ZzzQuil is marketed specifically as a sleep aid, while Benadryl is primarily used for allergy relief. Despite having the same active ingredient, the branding and intended use differ. It's important to use each product as directed for its intended purpose.

When considering long-term sleep medications, it is important to consult with a healthcare provider to determine the safest option based on individual health needs and conditions. Generally, medications like melatonin or certain low-dose antidepressants, such as trazodone, are sometimes considered for long-term use due to their relatively favorable safety profiles. However, non-pharmacological approaches, such as cognitive behavioral therapy for insomnia (CBT-I), are often recommended as the first-line treatment for chronic insomnia.

The choice between melatonin and diphenhydramine for sleep depends on the individual's specific needs and circumstances. Melatonin is a hormone that helps regulate the sleep-wake cycle and is often used for sleep disorders related to circadian rhythm disruptions, such as jet lag. It is generally considered safe for short-term use.Diphenhydramine, an antihistamine, is commonly used as a sleep aid due to its sedative properties. However, it may cause side effects such as dry mouth, dizziness, and next-day drowsiness. It is typically not recommended for long-term use as a sleep aid.It is advisable for individuals to consult with a healthcare provider to determine the most appropriate option based on their health status and sleep issues.