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This medication comes with important safety warnings and contraindications that you should be aware of before use. Please carefully review the following information and consult your healthcare provider if you have any questions or concerns:

• Severe Colitis Risk: Clindamycin, when absorbed through the skin, may occasionally lead to a serious inflammation of the colon known as colitis, which can be life-threatening. This risk is increased when clindamycin/benzoyl peroxide is used on the mouth, eyes, or damaged skin, or over an extended period. Additionally, individuals taking opioid pain medications, such as hydrocodone or oxycodone, or Lomotil, are at a heightened risk.

• Sun Sensitivity: While using clindamycin/benzoyl peroxide, your skin may become more sensitive to UV light, potentially leading to severe sunburn. To prevent this, limit sun exposure and avoid sunlamps and tanning beds during and immediately after treatment. When outdoors, seek shade and consider using sunscreen and protective clothing, such as hats and long-sleeved shirts.

• Skin Irritations: Combining clindamycin/benzoyl peroxide with other topical acne treatments may cause skin irritation, including peeling and flakiness. If you experience these symptoms, your dermatologist may recommend pausing treatment or reducing the frequency of use. In cases of severe irritation, it may be necessary to discontinue use and explore alternative treatments.

Contraindications highlight situations where the use of this medication is not recommended due to potential health risks:

• Lincomycin Allergy: Do not use this medication if you have an allergy to lincomycin.

• Inflammatory Gut Conditions: Individuals with a history of inflammatory bowel conditions, such as ulcerative colitis, antibiotic-associated colitis, or regional enteritis, should avoid using this medication. Consult your healthcare provider for guidance if you have these conditions.

When using this medication, some individuals may experience mild side effects, which are generally manageable. These include dry skin, redness, burning, itching, or skin peeling. In some cases, skin scaling may also occur. These effects are often temporary; however, if they persist or worsen, it is advisable to consult a healthcare provider. Utilizing moisturizing creams or lotions can be beneficial in alleviating these mild symptoms.

On rare occasions, this medication can lead to more severe side effects. One such serious concern is a condition caused by the bacteria C. difficile, which may present as persistent diarrhea, abdominal pain, cramping, or blood/mucus in stools. This condition can occur during or even weeks to months after discontinuing the treatment. It is crucial to seek medical attention immediately if these symptoms arise and to avoid using anti-diarrhea or opioid products as they might exacerbate the condition.

Additionally, although extremely rare, a serious allergic reaction could occur, characterized by symptoms such as rash, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. Immediate medical assistance is essential if any signs of an allergic reaction appear. Always remain vigilant for any other effects not mentioned here and consult a healthcare provider as necessary.