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This medication has specific warnings and contraindications that are crucial for ensuring safe use. Please read the following information carefully and discuss any concerns with your healthcare provider.

• Serious Intestinal Condition (Colitis): Although uncommon, the absorption of clindamycin through the skin can lead to a serious condition known as colitis, which involves inflammation of the colon. There is an increased risk for individuals using opioid pain relievers (such as hydrocodone/acetaminophen or oxycodone) or Lomotil (diphenoxylate/atropine). Risk factors include applying clindamycin/benzoyl peroxide to sensitive areas such as the mouth, eyes, or broken skin, prolonged use of the medication, and concurrent use with opioids or Lomotil.

• Sun Sensitivity: This medication may increase your skin’s sensitivity to ultraviolet (UV) light, potentially leading to severe sunburn. It is advisable to reduce sun exposure, avoid sun lamps and tanning beds while using this medication, and shortly thereafter. Consider using sunscreen and wearing protective clothing, like hats and long sleeves, if sun exposure is unavoidable.

• Skin Irritations: The combination of clindamycin/benzoyl peroxide with other topical acne treatments can lead to skin irritation, including peeling and flakiness. If irritation occurs, your dermatologist may recommend pausing or reducing the frequency of use. In cases of severe irritation, discontinuation of the treatment may be necessary.

Contraindications include:

• Allergy to Lincomycin: If you have a known allergy to lincomycin, this medication should not be used.

• History of Inflammatory Bowel Conditions: Individuals with a history of certain inflammatory bowel conditions, such as ulcerative colitis, antibiotic-associated colitis, or regional enteritis, should avoid this medication.

Always consult your healthcare provider for guidance tailored to your health needs.

When using this medication, some individuals might experience mild side effects such as skin redness, peeling, dryness, or a burning sensation. These symptoms are generally not serious, but if they persist or worsen, it is advisable to consult a healthcare provider. Moisturizing creams or lotions can help alleviate these common side effects.

In rare cases, the medication might be absorbed into the bloodstream and cause a severe intestinal condition linked to the bacteria C. difficile. This condition can manifest during treatment or even weeks to months afterward. If you notice persistent diarrhea, abdominal pain, or blood/mucus in your stool, seek medical attention immediately. Avoid using anti-diarrhea or opioid products as they may exacerbate the symptoms.

Though a severe allergic reaction to this medication is uncommon, it is critical to get medical help promptly if you experience symptoms such as rash, significant swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. These signs indicate a need for urgent medical care.

While these are not all the possible side effects, they highlight the importance of monitoring your health while using this medication. If you observe any other unusual effects, contact your healthcare provider for advice.