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The following information outlines crucial safety warnings and contraindications associated with the use of this medication. Review these carefully and reach out to your healthcare provider if you have any questions or concerns.

• Risk of Serious Gut Problems (Colitis): There is a rare but serious risk of developing colitis, an inflammation of the large intestine, when clindamycin is absorbed into the body. This risk is heightened for individuals using opioid pain medications (such as Norco or oxycodone) or Lomotil. Be cautious when applying Onexton (clindamycin/benzoyl peroxide) to areas such as the mouth, eyes, or broken skin, and avoid prolonged use. Consult your doctor if you are also taking opioids or Lomotil with Onexton.

• Sun Sensitivity: Onexton can make your skin more sensitive to ultraviolet (UV) light, increasing the risk of severe sunburn. Minimize exposure to sunlight, sun lamps, and tanning beds during and shortly after treatment. If you must be outside, try to stay in the shade and consider using sunscreen and protective clothing like hats and long sleeves. Discuss with your dermatologist the best ways to protect your skin from UV exposure.

• Skin Irritations: Combining Onexton with other topical acne treatments may cause skin irritation, such as peeling or flakiness. If irritation occurs, your dermatologist might recommend reducing usage or temporarily discontinuing treatment until the irritation subsides. In cases of severe irritation, stopping treatment altogether and exploring alternative options may be necessary.

Contraindications: Use of this medication is not recommended under certain conditions due to potential health risks. Consult your healthcare provider if any of the following apply to you:

• Allergy to lincomycin.
• A history of specific inflammatory gut conditions, such as ulcerative colitis, antibiotic-associated colitis, or regional enteritis.

When using this medication, some individuals may experience side effects. Common side effects include redness, dry skin, burning, itching, and skin peeling. These are generally mild and can often be alleviated with skin moisturizers. If these effects persist or worsen, it is important to consult with a healthcare provider.

Some users might also encounter scaling and stinging. While these are typically not severe, it is advisable to monitor these symptoms and seek guidance if necessary. The medication can rarely lead to a serious intestinal condition, possibly caused by C. difficile, which can manifest as persistent diarrhea, abdominal or stomach pain, cramping, and blood or mucus in the stool. It is crucial not to use anti-diarrhea or opioid products if these symptoms occur, and immediate medical attention is required.

Additionally, although very rare, a severe allergic reaction can occur. Symptoms such as hives, severe dizziness, trouble breathing, and swelling of the face, tongue, or throat necessitate urgent medical care. Always report any side effects to your healthcare provider to ensure appropriate management and support.