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This medication comes with several important safety warnings that should be reviewed carefully. Consultation with a healthcare provider is advised if there are any concerns.

• Hormone Issues and Withdrawal: Prolonged use of topical hydrocortisone over large skin areas may lead to adrenal suppression, a condition where your body reduces its natural steroid hormone production. Abrupt discontinuation can cause withdrawal symptoms such as skin swelling, rash, and burning. To minimize this risk, your healthcare provider will prescribe the lowest effective dose for the shortest duration. If long-term or extensive use is necessary, your provider may recommend tests to assess adrenal gland function. Do not stop using topical hydrocortisone suddenly without consulting your provider. Risks are higher with prolonged use, excessive application, covered areas, and in young children.

• Increased Blood Sugar: Extended use of topical hydrocortisone on large body areas may elevate blood sugar levels, potentially leading to diabetes. If you have diabetes, regular monitoring of blood sugar is advised to ensure safety. Notify your provider if you experience increased thirst or urination. Risks include prolonged use and using more than the recommended amount.

• New or Worsened Skin Infections: Long-term use may increase the likelihood of developing skin or mouth infections, including fungal and bacterial types. Do not apply topical hydrocortisone on infected skin, as it may exacerbate the infection. Inform your provider if you notice redness, swelling, pain, pus, or if your symptoms do not improve within 7 days, as these may indicate a new infection. Risks are heightened with usage exceeding 7 days.

• Skin Reactions: Extended use beyond your provider's direction can lead to skin issues such as thinning, stretch marks, spider veins, burning, itching, irritation, dryness, inflamed hair follicles, changes in skin color, or rash. To avoid severe reactions, your provider will aim to use the lowest effective dose for the briefest period. Report any new or worsening skin problems to your provider promptly. Risks are associated with excessive or inappropriate use.

Please adhere to these guidelines to ensure safe usage of topical hydrocortisone and consult your healthcare provider with any questions or concerns.

When using this medication, some individuals may experience mild side effects such as burning, itching, skin irritation, dryness, or inflamed hair follicles. These effects are generally not severe but should be discussed with a healthcare provider if they persist or worsen. Additionally, some users may notice acne-like bumps, changes in skin color, thinning skin, stretch marks, or unusual hair growth. These effects might also include skin pruning or wrinkling.

While many side effects are mild, there are instances where more significant reactions can occur. If the treated area starts to bleed, particularly when using the product for anal itching, seek medical attention immediately. Although rare, a serious allergic reaction may happen. Signs of such a reaction include a rash, severe dizziness, swelling, especially of the face, tongue, or throat, and trouble breathing. Immediate medical help is essential in these cases.

It's important to remember that not everyone will experience side effects, and for many, the benefits of the medication outweigh the risks. However, if you experience any effects not listed here or if any symptoms cause concern, reaching out to a healthcare provider is recommended.