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Hydrocortisone enema, known as Cortenema, is a treatment used to manage the symptoms of ulcerative colitis in adults. Although it does not cure the condition, it works by reducing inflammation and swelling in the lower intestine, which helps alleviate symptoms such as diarrhea and bloody stools. This medication is typically administered rectally once per night over a 21-day period. It belongs to a class of drugs called corticosteroids, which function by decreasing certain chemicals in the body that cause swelling and pain. Hydrocortisone enema is available in both brand-name and generic forms, and possible side effects include pain and bruising in the rectal area. It is important to use this medication as part of a comprehensive treatment plan under the guidance of a healthcare professional.