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You might experience some mild side effects such as drowsiness, dizziness, tiredness, dry mouth, nausea, headache, or difficulty sleeping. These are common and generally not a cause for concern. However, if they persist or worsen, it's important to seek advice from a healthcare professional.

Be alert for more serious side effects that require prompt medical attention. These include difficulty urinating, an irregular or pounding heartbeat, tremors, or changes in mood and mental state, such as anxiety or confusion. Weakness is also a sign to watch for and report to your healthcare provider.

In rare cases, very serious side effects like seizures can occur, and immediate medical assistance is necessary. Additionally, though uncommon, severe allergic reactions may happen. Seek urgent care if you experience symptoms like a rash, itching, swelling, severe dizziness, or difficulty breathing.

While this overview includes many possible side effects, it may not cover all of them. If you experience any other unusual symptoms, consulting with your healthcare provider is advisable. Your safety is important, and they can provide the best guidance tailored to your situation.

Avoid combining this medication with MAO inhibitors, as this can lead to a severe and potentially life-threatening interaction. MAO inhibitors include isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine. Do not take these inhibitors during your treatment with this drug, and most should be avoided for two weeks prior to starting this medication. Consult your doctor for guidance on when to begin or discontinue use.

Inform your doctor or pharmacist if you are using any other products that may cause drowsiness. This includes opioid pain or cough medications (such as codeine or hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as chlorpheniramine, diphenhydramine).

Review the labels on all your medicines, including those for allergies or cold symptoms, as they might contain ingredients that cause drowsiness or are similar, like decongestants such as phenylephrine. Consult your pharmacist to ensure safe use of these products.

Do not use other antihistamines applied to the skin, such as diphenhydramine creams, ointments, or sprays, while taking this medication, as this can increase side effects.

Cetirizine is closely related to hydroxyzine and levocetirizine. Do not take these medications together with cetirizine.

This medication may affect certain laboratory tests, such as allergy skin tests, and could lead to inaccurate results. Make sure that the lab staff and all your healthcare providers are aware that you are taking this medication.