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When taking this medication, you might experience some common side effects such as drowsiness, dizziness, tiredness, dry mouth, nausea, headache, or trouble sleeping. These symptoms are usually mild, but if they persist or worsen, it’s important to inform your healthcare provider.

In some cases, more serious side effects can occur, though they are less common. Be vigilant and notify your healthcare provider immediately if you experience difficulty urinating, a fast, irregular, or pounding heartbeat, trembling, or any mental or mood changes such as anxiety, confusion, nervousness, or restlessness. Additionally, if you feel unusually weak, it’s crucial to seek medical advice.

Severe side effects are rare but require immediate medical attention. These include seizures and serious allergic reactions characterized by a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or trouble breathing.

While these side effects cover a range of possibilities, it’s essential to remain aware and report any other unusual symptoms to your healthcare provider. Your vigilance can help manage any potential side effects effectively.

Avoid using MAO inhibitors with this medication, as it can lead to a severe, potentially life-threatening interaction. The list of MAO inhibitors includes isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine. These should generally not be taken during treatment with this medication, and in most cases, should be discontinued at least two weeks prior. Consult your doctor for guidance on when to start or stop this medication.

Inform your doctor or pharmacist if you are taking any other substances that may cause drowsiness. This includes opioid painkillers or cough suppressants like codeine or hydrocodone, alcohol, marijuana, sleep aids or anxiety medications such as alprazolam, lorazepam, or zolpidem, muscle relaxants like carisoprodol or cyclobenzaprine, or other antihistamines, such as chlorpheniramine or diphenhydramine.

Always check the labels of all your medications, including those for allergies or cough and cold, as they may contain drowsiness-inducing ingredients or similar compounds like decongestants (e.g., phenylephrine). Consult your pharmacist to ensure safe use of these products.

Do not apply other antihistamines to your skin, such as diphenhydramine creams, ointments, or sprays, to avoid increased side effects.

Cetirizine is closely related to hydroxyzine and levocetirizine. Do not take these medications together with cetirizine.

This medication could affect certain lab tests, such as allergy skin tests, which might result in inaccurate outcomes. Ensure that all your healthcare providers and lab technicians are aware that you are using this medication.