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When taking this medication, it is crucial to be aware of potential interactions and precautions to ensure safe use. Here are key safety guidelines to consider:

• MAO Inhibitors: Avoid taking MAO inhibitors (such as isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) with this medication due to the risk of a serious, possibly fatal interaction. It is generally advised not to take most MAO inhibitors for two weeks before starting this medication. Consult your doctor for specific guidance on starting or stopping this medication.

• Substances Causing Drowsiness: Inform your healthcare provider if you are using other products that may induce drowsiness. This includes opioid pain or cough relievers (e.g., codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or other antihistamines (e.g., chlorpheniramine, diphenhydramine).

• Medication Labels: Check all medication labels, especially those for allergy or cough-and-cold products, as they may contain ingredients that cause drowsiness or similar components like decongestants (e.g., phenylephrine). Consult your pharmacist about using these products safely.

• Topical Antihistamines: Do not use any other topical antihistamines (such as diphenhydramine cream, ointment, or spray) alongside this medication to avoid increased side effects.

• Similar Medications: Cetirizine is similar to hydroxyzine and levocetirizine. Avoid using these medications concurrently with cetirizine.

• Laboratory Tests: This medication might interfere with certain laboratory tests, such as allergy skin testing, potentially leading to false results. Ensure that all lab personnel and your doctors are aware of your medication use.

By following these guidelines, you can help ensure the safe and effective use of this medication. Always consult with a healthcare professional for personalized advice.

Common side effects:

• drowsiness
• dizziness
• tiredness
• dry mouth
• nausea
• headache
• trouble sleeping

Less common but important to monitor:

• difficulty urinating
• fast or irregular heartbeat
• shaking
• anxiety
• confusion
• nervousness
• restlessness

Serious side effects:

• seizures
• severe allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)

Interactions with low risk that usually do not require a change in therapy:

• Opioid pain or cough medications (codeine, hydrocodone)
• Alcohol
• Marijuana
• Sleep or anxiety medications (Alprazolam, Lorazepam, Zolpidem)
• Muscle relaxants (Carisoprodol, Cyclobenzaprine)
• Other antihistamines (chlorpheniramine, diphenhydramine)
• Topical antihistamines (diphenhydramine cream, ointment, spray)
• Hydroxyzine
• Levocetirizine
• Decongestants (phenylephrine)