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This medication carries several important safety considerations and precautions that users should be aware of. Please review the following information carefully and discuss any concerns with your healthcare provider.

• Pregnancy Warning: This medication should not be used during pregnancy as it can cause serious, potentially life-threatening harm to an unborn baby. It is essential to use effective birth control while taking this drug. If you are pregnant, planning to become pregnant, or suspect you might be pregnant, contact your healthcare provider immediately to discuss safer treatment options.

• Angioedema Risk: There is a rare but serious risk of angioedema, characterized by swelling in areas such as the face, throat, and tongue, which can obstruct breathing. This risk is higher in Black individuals, older adults, females, and those with a history of angioedema.

• Severe Allergic Reactions: Although rare, severe allergic reactions, including anaphylaxis, may occur. Seek immediate medical attention if you experience difficulty breathing, hives, or swelling of the face or throat.

• Liver Issues: Rare cases of life-threatening liver problems have been reported. If you experience symptoms like nausea, stomach pain, or yellowing of the skin or eyes, contact your healthcare provider immediately. Those with a history of liver problems or heavy alcohol use are at increased risk.

• Kidney Problems Worsening: While generally beneficial for kidney function, this medication can sometimes worsen kidney issues, particularly in individuals with renal artery stenosis or severe heart failure. Regular kidney function monitoring is recommended. Notify your provider if you notice a decrease in urination.

• Blood Cell Counts: Individuals with conditions such as lupus or rheumatoid arthritis may experience lower blood cell counts, especially if kidney issues are present. Regular blood tests may be necessary to monitor blood cell levels.

• Low Blood Pressure: This medication can cause a significant drop in blood pressure, leading to dizziness or lightheadedness, especially when starting the treatment or increasing the dose. Stay hydrated and sit down slowly if you feel dizzy. Contact your provider if symptoms persist or if you fall and hit your head.

• High Potassium Levels: Elevated potassium levels can occur, posing a risk of heart issues. This is more likely in individuals with diabetes, kidney problems, or those on other potassium-increasing medications. Report symptoms such as nausea, muscle weakness, or irregular heartbeat to your provider.

• Cough: A persistent dry cough may develop at any time during treatment. If this becomes bothersome, your provider may suggest an alternative medication. The cough typically resolves after discontinuation of the drug.

Contraindications: Do not use this medication if you are allergic to any ACE inhibitors, or if you are taking neprilysin inhibitors like Entresto (sacubitril/valsartan), or aliskiren (Tekturna) for high blood sugar. Discuss these factors with your healthcare provider before initiating treatment.

When taking this medication, you may experience some common side effects as your body adjusts. These include dizziness, lightheadedness, tiredness, headache, and dry cough. Typically, these effects are mild and should diminish over time. To help manage dizziness and lightheadedness, try rising slowly from sitting or lying positions.

Some users may experience low blood pressure and feelings of weakness. While these are generally not severe, it is important to monitor their persistence or worsening and consult a healthcare provider if necessary.

Although rare, serious side effects can occur and require immediate medical attention. Watch for signs such as fainting, severe dizziness, or symptoms of high potassium levels like muscle weakness and irregular heartbeat. Additionally, this medication might impact kidney function, so be vigilant for any changes in urine output.

In very rare cases, this drug can cause severe liver damage or allergic reactions. Symptoms of liver issues include persistent nausea, vomiting, loss of appetite, stomach pain, jaundice, or dark urine. Signs of a serious allergic reaction may include rash, swelling, particularly of the face, tongue, or throat, and difficulty breathing. If you notice these severe symptoms, seek medical help promptly. Always contact your healthcare provider with concerns about side effects, as this is not an exhaustive list.

Ramipril can interact with several medications, and it's important to inform your doctor and pharmacist about all the drugs and supplements you are taking, whether they are prescription, over-the-counter, vitamins, or herbal products.

Some medications should not be combined with Ramipril, such as Aliskiren and Sacubitril, due to the risk of serious interactions. Other drugs, such as Everolimus, Sirolimus, Lithium, and those that can raise potassium levels (including certain ARBs like Losartan and Valsartan, and drospirenone-containing birth control), may require adjusted dosages or careful monitoring if used together with Ramipril.

Additionally, certain products may elevate blood pressure or worsen heart failure. It's advisable to consult your pharmacist when using cough-and-cold products, diet aids, or NSAIDs (e.g., Ibuprofen, Naproxen) to ensure safe usage with Ramipril.

A specific concern exists for those undergoing desensitization therapy for bee or wasp stings, as taking Ramipril can lead to a severe reaction. Always keep your healthcare providers informed about all the medications you are taking to avoid potential interactions.