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This medication carries several important safety warnings that must be carefully considered. Patients and healthcare providers should be aware of potential risks, necessary precautions, and the steps to take in case of adverse effects.

• Use During Pregnancy: This medication can cause severe harm to an unborn child and should not be used during pregnancy. It is crucial to use effective contraception while taking this medication. If you are pregnant, planning to become pregnant, or suspect you might be pregnant, consult your healthcare provider immediately to discuss safer alternatives.

• Angioedema Risk: Users of ACE inhibitors, including this medication, may experience angioedema. This serious condition involves swelling, particularly of the face, throat, and tongue, and can be life-threatening. Immediate medical attention is necessary if swelling or difficulty breathing occurs. Certain populations, such as Black individuals, older adults, and females, may have a higher risk.

• Low Blood Pressure: This medication can occasionally cause a significant drop in blood pressure, resulting in dizziness, fatigue, or lightheadedness, especially when starting treatment or adjusting dosage. Ensure adequate hydration and contact your healthcare provider if symptoms occur. In case of a fall, seek medical help immediately.

• Kidney Function: While generally beneficial to the kidneys, this medication may exacerbate kidney issues in some cases. Regular monitoring of kidney function is necessary, particularly for those with pre-existing kidney conditions or severe heart failure. Any reduction in urination should be reported to your healthcare provider.

• High Potassium Levels: The medication may increase potassium levels, posing a risk of heart complications. Individuals with diabetes, kidney issues, or those on other potassium-raising medications are at higher risk. Symptoms like nausea, muscle weakness, or irregular heartbeat should be promptly reported to a healthcare provider.

• Liver Issues: Rarely, this medication can cause liver problems or failure, particularly in individuals with a history of liver issues or heavy alcohol use. Regular liver function tests may be required. Symptoms such as fatigue, abdominal pain, or jaundice should be reported immediately.

Contraindications:

• Do not use this medication if you have a history of angioedema.
• Avoid concurrent use with aliskiren (Tekturna) if you have high blood sugar.
• Do not take it with neprilysin inhibitors, such as sacubitril/valsartan (Entresto), within 36 hours.

In case of overdose or adverse reactions, seek emergency medical assistance promptly. Always consult with your healthcare provider regarding any potential interactions with other medications or conditions.

When taking this medication, some people may experience common side effects such as dizziness, which can affect up to 19% of users, low blood pressure occurring in 7-11%, higher creatinine levels in 7-10%, and headaches in about 6% of cases. Additionally, a dry cough and occasional feelings of faintness may occur. These effects are typically mild, but if they persist or worsen, it's advisable to consult your healthcare provider.

On the more serious side, although rare, there are severe side effects that demand immediate medical attention. Angioedema is a severe swelling that can affect the face, arms, legs, lips, tongue, or throat. Dangerously low blood pressure may cause dizziness, lightheadedness, or a pale complexion. Serious kidney issues can manifest as reduced urination, swelling in the extremities, or unexplained weight gain. High potassium levels in the blood might result in nausea, muscle weakness, or abnormal heartbeats. Severe liver problems could present with symptoms like stomach swelling, yellowing of the skin or eyes, confusion, or dark urine. Lastly, a severe allergic reaction might occur, characterized by swelling of the lips, tongue, throat, or face, difficulty breathing, or a rash.

It's important to monitor for these symptoms and seek medical help if any severe side effects occur. Always communicate with your healthcare provider regarding any concerns about side effects.

Lisinopril, also known as Zestril, can interact with various medications and supplements. It is important to inform your healthcare provider and pharmacist about all the medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products.

Certain medications should not be used with lisinopril. These include Aliskiren and sacubitril, as they may lead to adverse effects. In some cases, your doctor might need to adjust your treatment plan if these are necessary.

Other medications, such as Everolimus, Sirolimus, and Lithium, may require careful monitoring if used with lisinopril, as they can alter its effectiveness or increase the risk of side effects. Additionally, drugs that elevate blood potassium levels, like ARBs (Losartan, Valsartan) and birth control pills containing drospirenone, need cautious use with lisinopril.

Over-the-counter products, including NSAIDs like Ibuprofen and Naproxen, as well as certain cough-and-cold remedies and diet aids, may also pose risks when used with lisinopril. These can potentially elevate blood pressure or worsen heart failure. Be sure to consult with your pharmacist on how to safely use these products.

Lastly, if you are undergoing allergy desensitization treatment for bee or wasp stings while taking lisinopril, inform all your doctors, as a serious reaction could occur.