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This medication comes with important safety warnings that you should carefully consider. Be sure to discuss any concerns with your healthcare provider.

• Proper Use: It is crucial to follow your healthcare provider’s instructions when using topical lidocaine. Applying it more frequently or in larger amounts than directed can lead to an accumulation in your body, increasing the risk of severe side effects. Do not use topical lidocaine on infected or severely damaged skin without consulting your doctor, as these conditions may cause excessive absorption. Overuse can result in serious complications such as seizures, breathing difficulties, low blood pressure, a slow heart rate, and potential cardiac arrest. Seek immediate medical attention if you experience any of these symptoms.

• Methemoglobinemia Risk: Topical lidocaine, particularly 5% ointment and LiDORx 3% gel, can induce methemoglobinemia, a critical blood disorder that impairs oxygen delivery to your body. This risk is elevated in individuals with low glucose-6-phosphate dehydrogenase (G6PD) levels, a hereditary condition that affects red blood cell stability. Caution is advised if you are frequently exposed to oxidizing chemicals such as chlorine and hydrogen peroxide, which are common in household cleaning products and hair dyes. Methemoglobinemia symptoms can appear immediately or hours after application and include headache, fatigue, and bluish skin. Prompt medical intervention is necessary to prevent severe consequences like seizures, unconsciousness, and cardiac arrhythmias (rapid heartbeat, dizziness, shortness of breath).

Special populations at higher risk include individuals with a history of methemoglobinemia, G6PD deficiency, heart or lung issues, those under six months of age, and those exposed to oxidizing agents.

In case of overdose or if you experience any concerning symptoms, seek emergency medical assistance without delay.

AneCream, a topical anesthetic containing Lidocaine, is generally safe for use. However, certain interactions and precautions should be considered to ensure its safe application.

Drug Interactions:

While AneCream is applied externally and has minimal systemic absorption, it can still interact with other medications. Notably, there are 79 known drug interactions associated with AneCream, including 2 major, 70 moderate, and 7 minor interactions. For instance, combining AneCream with other local anesthetics or certain antiarrhythmic drugs may increase the risk of side effects. Therefore, it's essential to inform your healthcare provider about all medications you're currently using, including over-the-counter drugs and supplements.

Food and Alcohol Interactions:

There are no specific food interactions associated with AneCream. However, it's advisable to avoid consuming alcohol while using this medication, as alcohol can enhance the nervous system side effects of lidocaine, such as dizziness and drowsiness.

Disease Interactions:

Certain medical conditions may affect the safety and efficacy of AneCream. These include:

• Cardiovascular Dysfunction: Individuals with heart problems should use AneCream cautiously, as lidocaine can affect heart rhythm.

• Hepatic Dysfunction: Liver disease can alter the metabolism of lidocaine, potentially leading to increased side effects.

• Renal Dysfunction: Kidney issues may affect the excretion of lidocaine, necessitating dosage adjustments.

• Seizures: Lidocaine can lower the seizure threshold; therefore, individuals with a history of seizures should consult their doctor before use.

Special Precautions:

• Application on Damaged Skin: Avoid applying AneCream to areas with open wounds, infections, or damaged skin, as this can increase systemic absorption and the risk of adverse effects.

• Use in the Mouth or Throat: If applying AneCream in the mouth or throat, refrain from eating or chewing gum for at least one hour to prevent choking or biting injuries due to numbness.

• Allergic Reactions: Be aware of potential allergic reactions. If you experience symptoms such as difficulty breathing, swelling, or rash, seek medical attention immediately.

Always consult your healthcare provider before starting or stopping any medication, including AneCream, to ensure it is appropriate for your specific health conditions and to avoid potential interactions.