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This medication requires careful consideration of the following safety and warning information to minimize potential risks. Please review these points and consult with your healthcare provider if you have any concerns:

• Allergic Reactions: Be aware that allergic reactions to dibucaine (Nupercainal) or its components can occur. If you experience any symptoms such as redness, irritation, swelling, or pain, discontinue use immediately and contact your healthcare provider.

• Contraindications: This medication should not be used in certain situations due to possible severe health risks. Specifically, it is contraindicated for use in children under 2 years of age. If this applies to you, seek advice from your healthcare provider before using this medication.

Common side effects:

• Temporary redness
• Mild stinging
• Slight swelling
• Irritation
• Pain at the application site

Serious side effects:

• Slow or shallow breathing
• Seizures
• Pale or bluish-gray skin
• Unusual tiredness
• Shortness of breath
• Fast, slow, or irregular heartbeat
• Rash
• Itching
• Hives
• Swelling of the face, lips, tongue, or throat
• Severe dizziness
• Trouble breathing

Dibucaine is a topical anesthetic commonly used to relieve pain and itching from conditions like hemorrhoids, minor burns, and insect bites. While it is generally safe when used as directed, it's important to be aware of potential interactions with other medications.

One notable interaction involves Metoclopramide, a medication used to treat nausea and gastrointestinal issues. When used together, dibucaine and metoclopramide can increase the risk of methemoglobinemia—a rare condition where the blood's ability to carry oxygen is reduced. This risk is higher in individuals who are very young, have anemia, heart or lung diseases, or certain genetic conditions. Symptoms of methemoglobinemia may include gray or blue skin color, headache, dizziness, fatigue, shortness of breath, and a rapid heartbeat. If you experience any of these symptoms, seek medical attention immediately.

Similarly, combining dibucaine with medications like amyl nitrite or isosorbide dinitrate can also elevate the risk of methemoglobinemia. Therefore, it's crucial to inform your healthcare provider about all medications you're currently taking, including over-the-counter drugs and supplements, before using dibucaine.

Additionally, using dibucaine on large areas of the body, broken skin, or mucous membranes can lead to increased absorption into the bloodstream, potentially heightening the risk of side effects. Always follow the recommended dosage and application instructions, and consult your doctor if you have any concerns or if your symptoms persist.