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The safety information provided below is crucial for understanding the risks associated with Arcalyst (rilonacept). Please read carefully and consult your healthcare provider with any concerns.

• Risk of Serious Infections: Arcalyst (rilonacept) may compromise your or your child's immune system, increasing susceptibility to serious infections such as sinus infections, bronchitis, tuberculosis (TB), and meningitis. Avoid concurrent use with medications like corticosteroids or TNF blockers, which can further elevate infection risk. Discuss with your healthcare provider if you have:

  • Active, chronic, or recurrent infections
  • A history of immune system issues, like diabetes or HIV
  • Lung conditions such as asthma or TB
  • Current use of other immune-suppressing medications

• Elevated Cholesterol and Triglycerides: Use of Arcalyst (rilonacept) might lead to increased blood cholesterol and triglyceride levels, which over time could heighten the risk of heart-related issues, including chest pain, heart attack, or stroke. Regular blood tests may be necessary to monitor these levels.

• Vaccine Interactions: Arcalyst (rilonacept) may interact with vaccines, potentially reducing their effectiveness, particularly live vaccines such as MMR (measles, mumps, rubella). Increased infection risk after live vaccines is possible. Avoid receiving live vaccines while on this medication. Consult your healthcare provider regarding your or your child's vaccination history to ensure all vaccines are current.

• Potential Cancer Risk: The risk of cancer with Arcalyst (rilonacept) use is unclear. However, similar immunosuppressive drugs have been linked to increased cancer risk. Discuss any concerns with your healthcare provider to determine if Arcalyst (rilonacept) is suitable for you.

No specific contraindications are available for Arcalyst (rilonacept). Always consult your healthcare provider to tailor the use of this medication to your health needs.

When using this medication, some common side effects include pain, itching, and swelling at the injection site, which typically resolve within a day or two. Occasionally, individuals may also experience upper respiratory tract infections, such as a sore throat or nasal congestion. These effects are usually mild, but if they persist or worsen, consulting a healthcare provider is advisable.

Other side effects that have been reported include cough, numbness, nausea, diarrhea, abdominal discomfort, and urinary tract infections. While these are generally manageable, it's important to reach out to a healthcare professional if they become bothersome.

Rarely, the medication can lead to serious side effects that require immediate medical attention. These include symptoms of tuberculosis, such as coughing up blood, weight loss, and persistent fatigue, as well as signs of bacterial meningitis, like fever, severe headache, and neck stiffness. Other serious infections might present with fever, cough, or body aches. If any of these symptoms occur, seeking urgent medical care is crucial.

Although a severe allergic reaction is rare, if you experience symptoms like a rash, significant swelling, severe dizziness, or difficulty breathing, it's important to get medical help promptly. This drug can also impact cholesterol and lipid levels in the blood, so periodic lab tests may be necessary to monitor these changes. If you notice any side effects not listed here, contacting a healthcare provider is recommended.