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Anakinra is used to treat rheumatoid arthritis. It helps to slow joint damage and reduces the joint pain/swelling so that you can move better. It is also used to treat a certain group of inherited disorders called cryopyrin-associated periodic syndromes (CAPS), including neonatal-onset multisystem inflammatory disease (NOMID). It helps to improve symptoms of NOMID such as fever, rash, joint pain, vomiting, and headache. Anakinra may also be used to treat another condition called Deficiency of Interleukin-1 Receptor Antagonist (DIRA), a condition where your body does not produce the natural protein interleukin-1 receptor antagonist. Anakinra is a man-made form of a natural protein (interleukin-1 receptor antagonist) made by the body. It helps to block the effects of another protein (interleukin-1) which can cause symptoms such as joint pain/swelling/stiffness. The FDA is allowing the emergency use of anakinra to treat coronavirus disease (COVID-19) in hospitalized patients with pneumonia and who also need supplemental oxygen. If anakinra is used to treat coronavirus disease, more information about the drug is available from the patient information sheet provided by your health care professional.