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The following information outlines crucial safety warnings and contraindications associated with the use of Kineret (anakinra). It is essential to review these details and discuss any concerns with your healthcare provider.

• Risk of Serious Infections: Kineret (anakinra) may impair your immune system’s ability to combat infections, increasing the likelihood of bacterial, viral, or fungal infections. Individuals currently on or having recently used other immune-suppressing medications are at heightened risk. Kineret (anakinra) can also reactivate dormant viruses such as tuberculosis (TB), posing significant health risks. If you exhibit symptoms like fever, cough, breathing difficulties, or weakness, inform your healthcare provider. You may need to halt Kineret (anakinra) until the infection is resolved. Elevated risk groups include those with active, chronic, or recurrent infections or those on other immune-suppressing drugs.

• Severe Allergic Reactions: There is potential for severe allergic reactions to Kineret (anakinra), including life-threatening conditions like anaphylaxis. This risk is notably higher in patients treated for DIRA, particularly within the initial weeks of treatment. Seek immediate medical attention if you experience dizziness, a choking sensation, nausea, or swelling of the face, lips, or tongue after using Kineret (anakinra).

• Vaccines: There is limited data on how Kineret (anakinra) affects vaccine efficacy, especially live vaccines. It is advisable to ensure vaccinations are up-to-date before starting Kineret (anakinra). Consult your healthcare provider prior to receiving any vaccines during treatment and avoid live vaccines to prevent possible illness.

Contraindications:

• Do not use Kineret (anakinra) if you have an allergy to proteins derived from E. coli. Prior to starting this medication, discuss any known allergies with your healthcare provider to prevent serious health risks.

When using this medication, some individuals may experience common side effects, which are generally mild and manageable. These include reactions at the injection site such as redness, bruising, swelling, and pain, which can last for 2 to 4 weeks. It's also common to have a sore throat, runny nose, headache, nausea, or diarrhea, with varying incidence rates. If these symptoms persist or worsen, reaching out to a healthcare provider is advisable for reassurance and guidance.

In some cases, other side effects like vomiting, joint stiffness, fever, or additional injection-site reactions may occur. While these are less common, they should still be monitored, and any persisting or worsening symptoms should be discussed with a healthcare professional to ensure comfort and safety.

Serious side effects are rare but require immediate medical attention due to their severity. These include significant joint stiffness, chills, body aches, flu-like symptoms, and stomach pain. Additionally, any signs of a serious infection, such as a persistent sore throat, fever, swollen lymph nodes, or cough, should prompt urgent medical evaluation. Severe allergic reactions, although very rare, need immediate attention if symptoms such as rash, itching, difficulty breathing, or swelling of the face, tongue, or throat occur. Always remain vigilant and prioritize health by seeking timely medical assistance when needed.