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Actemra (tocilizumab) is a medication that can present certain risks and requires specific precautions during use. Here is a summary of important safety information to consider before and during treatment:

• Infection Risks: Actemra may impair your immune system, increasing the likelihood of serious infections including bacterial, viral, or fungal. This risk is heightened if you are using other immune-suppressing drugs, such as methotrexate or corticosteroids. The medication can also reactivate viruses like tuberculosis (TB) or hepatitis B. It is crucial to inform your healthcare provider of your medical history, especially any past infections, and watch for infection symptoms such as fever, persistent sore throat, cough, or difficulty breathing. Medical assistance should be sought immediately if these symptoms occur. Your doctor will test you for TB before starting treatment and monitor for TB symptoms during and after using Actemra.

• Stomach and Intestinal Risks: This medication can increase the risk of tears or blockages in the stomach or intestines, especially if you have a history of related issues or are taking NSAIDs. Discontinue use and contact your healthcare provider immediately if you experience severe stomach pain or blood in your urine or stool.

• Liver Health: Actemra may lead to serious liver problems, potentially resulting in liver failure. Your provider will conduct liver function tests before and during treatment. Seek urgent medical attention if you notice symptoms like yellowing skin or eyes, dark urine, severe nausea, or confusion. You may need to stop the medication to prevent liver damage.

• Allergic Reactions: Severe allergic reactions can occur, including anaphylaxis. Signs include facial swelling, difficulty breathing, or dizziness. Immediate medical intervention is necessary if these symptoms appear.

• Blood Cell Counts: Actemra may lower white blood cell (WBC) and platelet counts, increasing infection and bleeding risks. Regular blood tests will be conducted to monitor these counts. Alert your provider if you notice symptoms like unusual fatigue or bleeding.

• Cholesterol Levels: The medication can elevate cholesterol levels. Regular cholesterol monitoring will be necessary, and lifestyle modifications such as a balanced diet and exercise are recommended. Your provider might prescribe cholesterol-lowering medication if needed.

• Vaccinations: It's advisable to be up-to-date with all vaccinations before starting Actemra. Avoid live vaccines during treatment, and discuss any vaccinations with your healthcare provider.

If you experience any concerning symptoms or have questions about this medication, contact your healthcare provider promptly. Always follow your provider's instructions and attend all scheduled appointments for monitoring while on Actemra.

When taking this medication, some common side effects may occur, which are usually mild. These include headaches, upper respiratory tract infections, high blood pressure, and elevated liver enzymes. Additionally, irritation, redness, or pain at the injection site might be experienced. If any of these persist or worsen, it's important to consult with your healthcare provider for guidance.

Other side effects that have been observed include dizziness, bronchitis, rash, mouth sores, and stomach pain. While these are generally not severe, it's advisable to speak with your healthcare provider if they cause concern or discomfort.

There are rare but serious side effects associated with this medication that require immediate medical attention. These include severe stomach or abdominal pain that does not subside, changes in bowel movements, and signs of serious infections such as fever, chills, or trouble breathing. Additionally, symptoms indicating liver problems, like persistent nausea, loss of appetite, yellowing of the skin or eyes, and dark urine, should prompt urgent care. A very serious allergic reaction, though uncommon, can occur, characterized by rash, swelling, severe dizziness, or difficulty breathing. If these symptoms appear, seek emergency medical help right away.

Always remain attentive to how your body responds to the medication and report any unusual effects to your healthcare provider to ensure your safety and well-being.

When using Actemra (tocilizumab), it's important to be aware of potential drug interactions. This medication can interact with other drugs that impact the immune system, such as certolizumab and corticosteroids like Prednisone. Additionally, Actemra can accelerate the elimination of certain medications from your body, which might alter their effectiveness. Some drugs affected include Omeprazole, Warfarin, and cholesterol-lowering medications like Atorvastatin, Lovastatin, and Simvastatin.

Actemra may also reduce the effectiveness of hormonal birth control methods, such as pills, patches, or rings, potentially leading to pregnancy. It's advisable to consult with your healthcare provider about using additional reliable birth control methods while on this medication. Report any new spotting or breakthrough bleeding to your doctor, as these could indicate reduced birth control efficacy.

Furthermore, Actemra may interact with several vaccines and other medications, including but not limited to abatacept, Tofacitinib, and various live vaccines such as those for measles, mumps, rubella, and yellow fever. If these medications or vaccines are necessary, your doctor might adjust the dosage or frequency of administration. Always inform your healthcare provider about all medications and supplements you are taking to avoid possible interactions.