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This medication comes with several important safety warnings that you should review. If you have any questions or concerns, please consult your healthcare provider.

• Breathing Difficulties: Tobramycin (Tobi) may cause bronchospasm, leading to breathing difficulties. If you experience wheezing or difficulty breathing, contact your healthcare provider. If you use a rescue inhaler, keep it accessible when starting this medication.

• Hearing Impairment: Tobramycin (Tobi), an aminoglycoside antibiotic, may result in hearing loss, dizziness, or vertigo. Initial symptoms can include ear ringing. Report any of these symptoms to your healthcare provider promptly. They may monitor your hearing and check tobramycin blood levels if necessary, particularly if you have a history of ear or balance issues.

• Kidney Health: Although rare with tobramycin (Tobi), as it primarily remains in the lungs, this antibiotic can cause kidney injury if blood levels become too high. Inform your provider if you experience reduced urine output or swelling in your legs and feet, as these may indicate kidney problems. Monitoring may be necessary if you have pre-existing kidney issues or are taking other medications that affect the kidneys.

• Muscle Weakness: Tobramycin (Tobi) has the potential to cause muscle weakness, particularly in individuals with neuromuscular conditions such as myasthenia gravis or Parkinson's disease. In severe cases, this could lead to paralysis or breathing difficulties. Immediate medical attention is required if you notice any muscle weakness.

• Pregnancy Risks: Using tobramycin (Tobi) during pregnancy may pose a risk to an unborn child. Although the medication predominantly remains in the lungs, it is crucial to discuss potential risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant.

There are no known contraindications associated with this medication. Always follow your healthcare provider’s instructions and report any concerning symptoms immediately.

When taking this medication, you may experience some common side effects that are usually mild and manageable. These include hoarseness, mouth or throat pain, cough, shortness of breath, wheezing, and a "rattling" sound in the lungs. Other possible side effects include a stuffy nose, throat irritation, changes in taste, nausea, vomiting, diarrhea, and headaches. Some individuals may also experience chest muscle pain, bleeding, changes in blood cell counts, high blood sugar, infections, fever, or a rash. Typically, these effects are temporary, but if they persist or worsen, consult your healthcare provider.

However, there are serious side effects that, although rare, should not be ignored. These include difficulty breathing, significant wheezing, hearing loss, dizziness, ringing in the ears, and muscle weakness. Additionally, signs of kidney problems such as reduced urine output or swelling in the feet or legs warrant immediate medical attention. A very serious allergic reaction is also rare, but watch for symptoms such as a rash, severe dizziness, swelling of the face, tongue, or throat, and trouble breathing. Seek urgent medical care if you experience any of these severe symptoms to ensure your safety and well-being.

Tobramycin may interact with certain medications, potentially increasing the risk of hearing loss or other side effects. It is important to inform your doctor and pharmacist about all medications and supplements you are taking, including prescribed, over-the-counter, vitamins, and herbal products.

Certain drugs, such as Amikacin, gentamicin, and mannitol, can heighten the risk of hearing damage when combined with tobramycin. Additionally, using tobramycin with medications like Ataluren is generally not recommended, and alternative treatments may be necessary.

In some cases, medications like Alcuronium, Atracurium, and Furosemide, among others, should be used cautiously with tobramycin. Your doctor might need to adjust doses if both are necessary. Lastly, drugs such as Cisplatin and Cyclosporine may increase specific side effects when used with tobramycin, but they might still be required for your treatment plan. Your healthcare provider will decide the best course of action, potentially altering dosages to minimize risks.