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Cyclosporine is a medication that requires careful consideration due to its potential risks and necessary precautions. Below is a summary of important safety information and warnings for users of cyclosporine:

• Infection Risk and Cancer Potential:

  • Cyclosporine can lower your immune system's ability to fight infections, increasing the risk of serious infections or worsening existing ones. It may also elevate the risk of developing certain cancers, such as skin cancer and lymphoma.
  • Watch for signs of infection or cancer, including persistent sore throat, fever, chills, cough, urinary issues, unusual skin changes, changes in moles, unexplained weight loss, swollen lymph nodes, lumps, or night sweats, and report these to your doctor immediately.

• Kidney and Liver Concerns:

  • This medication can cause kidney damage, especially at high doses or when used with other kidney-affecting drugs. Regular monitoring of kidney function is essential.
  • Liver problems may occur, particularly in those with pre-existing liver conditions or when combined with liver-harming medications. Regular liver function tests are crucial, especially during the initial month of treatment.

• Medication Absorption and Brand Differences:

  • The absorption of cyclosporine can vary. Different brands or forms (e.g., Sandimmune, Gengraf, Neoral) are not interchangeable. Switching brands or forms without medical guidance can lead to inappropriate medication levels, affecting efficacy and safety.

• Blood Pressure and Neurological Effects:

  • High blood pressure is a common side effect and may require additional medication to manage. Blood pressure should be regularly monitored.
  • Some individuals may experience neurological side effects affecting brain function, nerves, and movement. Symptoms like seizures, changes in consciousness, or vision problems should be reported, as dose adjustment may be needed.

• Cancer Risk and Sun Exposure:

  • Long-term use or high doses of cyclosporine may increase cancer risk. Limit sun exposure by wearing protective clothing and using sunblock.

• Vaccination Considerations:

  • Avoid live vaccines while on cyclosporine, as the medication alters immune response. Inform healthcare providers of cyclosporine use prior to vaccinations.

• Specific Risks and Contraindications:

  • Avoid cyclosporine if allergic to polyoxyethylated castor oil. Discuss any pre-existing conditions or medications with your healthcare provider.

• Emergency Situations:

  • In case of suspected overdose or severe adverse reactions, seek immediate medical attention.

This information emphasizes the importance of regular medical supervision and communication with healthcare providers when using cyclosporine to manage its risks effectively.

Common side effects:

• Shaking
• Headaches
• Dizziness
• Gastrointestinal issues such as nausea, vomiting, diarrhea, and stomach upset
• Unusual hair growth
• High blood pressure
• Gum overgrowth

Serious side effects:

• Kidney problems (changes in urine output or swelling in the legs)
• Liver damage (persistent nausea, dark urine, or jaundice)
• Muscle weakness
• Irregular heartbeat
• Numbness
• Severe leg pain
• Neurological issues (vision changes, speech problems, or seizures)
• Severe allergic reaction (rash, swelling, severe dizziness, or breathing difficulties)

Interactions with high risk of serious adverse effects and should be avoided:

• natalizumab
• rituximab
• Tofacitinib
• Tacrolimus

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Coal Tar
• Orlistat
• potassium supplements
• Amiloride
• Spironolactone
• bosentan
• Mifepristone
• St. John's wort
• Ritonavir
• Aliskiren
• Dabigatran
• dronedarone
• elagolix
• resmetirom
• Pitavastatin
• Simvastatin
• voxilaprevir