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When considering the use of this medication, it is crucial to understand the associated safety information and warnings. Below are the key points you should be aware of:

• Serotonin Syndrome: This rare but serious condition arises from excessive serotonin in the brain. The risk increases if buspirone is taken with other substances that elevate serotonin levels, like certain antidepressants, migraine, and pain medications. Inform your pharmacist about all medications and over-the-counter products you're using to avoid interactions. Seek immediate medical attention if you experience symptoms such as rapid heartbeat, sweating, muscle stiffness or spasms, fever, or confusion.

• Impact on Alertness: Buspirone's effects on concentration can vary, causing drowsiness or increased wakefulness. Until you know how it affects you, avoid engaging in activities that require full attention, such as driving or operating heavy machinery. The risk of drowsiness is heightened if you consume alcohol or take other medications with similar side effects.

• Transitioning from Benzodiazepines: If you're switching from benzodiazepines to buspirone, it is important to gradually reduce the benzodiazepine dosage under medical supervision. Buspirone does not alleviate withdrawal symptoms from benzodiazepines, which can include nausea, vomiting, diarrhea, and headaches. Notify your healthcare provider if you experience any withdrawal symptoms.

• Interaction with MAOIs: Combining buspirone with monoamine oxidase inhibitors (MAOIs) can dangerously elevate blood pressure. It is essential to avoid taking these medications together or within 14 days of each other. Disclose all current medications to your healthcare provider and pharmacist before starting buspirone.

Contraindications:

• Do not use this medication if you are currently taking MAOIs or have taken them in the last 14 days, as this could lead to serious health risks. Always consult your healthcare provider if you have any concerns or questions regarding these contraindications.

Common side effects:

• dizziness
• drowsiness
• nausea
• headache
• nervousness
• feeling tired
• dry mouth
• trouble sleeping
• lightheadedness
• restlessness
• blurred vision
• mild nervousness

Serious side effects:

• movement disorders
• serotonin syndrome
• allergic reactions

Interactions with high risk of serious adverse effects and should be avoided:

• Isocarboxazid
• Linezolid
• Phenelzine
• Tranylcypromine
• Moclobemide
• Selegiline
• Procarbazine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Alprazolam
• Amitriptyline
• Trazodone
• Codeine
• Hydrocodone
• Diltiazem
• Erythromycin
• Fluoxetine
• Itraconazole
• Nefazodone
• Rifampin
• St John's Wort

Interactions with low risk that usually do not require a change in therapy:

• Alcohol
• Marijuana
• Zolpidem
• Cetirizine
• Diphenhydramine