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While using this medication, you may experience mild side effects such as dizziness, drowsiness, headache, nausea, nervousness, lightheadedness, restlessness, blurred vision, tiredness, and trouble sleeping. These are generally not serious, but if they persist or worsen, it is advisable to consult your healthcare provider.

In rare instances, some individuals may develop movement disorders, including tremors, muscle stiffness, a mask-like facial expression, jerky walking movements, or tardive dyskinesia. These conditions can potentially become permanent, so it's crucial to inform your doctor immediately if you notice any unusual or uncontrolled movements, particularly of the face, mouth, tongue, arms, or legs.

Seek urgent medical attention if you experience severe side effects such as easy bleeding or bruising, shortness of breath, chest pain, or a rapid or irregular heartbeat. Though it is uncommon, a serious allergic reaction may occur, characterized by symptoms like rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. If any of these occur, get medical help right away.

This summary does not cover all potential side effects. If you observe any other unusual reactions, please contact your healthcare provider for further advice.

Certain medications can interact with this drug. These include antidepressants like SSRIs (such as fluoxetine), tricyclic antidepressants (such as amitriptyline and nortriptyline), and trazodone, as well as haloperidol. Using MAO inhibitors with this medication can lead to a severe, potentially fatal interaction. Do not take MAO inhibitors—such as isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine—while on this drug. It is also advised to avoid most MAO inhibitors for two weeks before and after using this medication. Consult your doctor about when to begin or discontinue the medication.

Other drugs can affect how your body processes buspirone, which may change its effectiveness. These include azole antifungals (like itraconazole), corticosteroids (such as dexamethasone), diltiazem, nefazodone, rifamycins (like rifabutin), ritonavir, and seizure medications (such as phenytoin and phenobarbital).

Inform your doctor or pharmacist if you are using other products that cause drowsiness. This includes opioid pain or cough relievers (such as codeine and hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety drugs (like alprazolam, lorazepam, and zolpidem), muscle relaxants (such as carisoprodol and cyclobenzaprine), or antihistamines (like cetirizine and diphenhydramine).

Always check the labels of all your medications, including those for allergies or cough and cold, as they might have drowsiness-inducing ingredients. Your pharmacist can provide guidance on the safe use of these products.

This drug might interfere with certain medical or laboratory tests, such as brain scans for Parkinson's disease, leading to incorrect results. Ensure that all medical personnel and your doctors are aware that you are taking this medication.