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Prochlorperazine is a medication with several important safety considerations and warnings. It is crucial for patients and healthcare providers to discuss these risks and make informed decisions about its use.

• Increased Risk in Older Adults with Dementia: There is a heightened risk of death when prochlorperazine is used to treat dementia-related psychosis in individuals over 65. This medication is not approved for this condition, so disclose any history of dementia to your healthcare provider prior to starting treatment.

• Uncontrolled Muscle Movements: Prochlorperazine may lead to tardive dyskinesia, characterized by uncontrollable muscle movements, which can be permanent. To minimize risk, use the lowest effective dose for the shortest duration. Notify your healthcare provider immediately if you observe involuntary movements. This risk is higher in older adults, females, and those taking higher or prolonged doses.

• Other Muscle Movement Disorders: Additional movement disorders like dystonia and Parkinsonian symptoms may occur, often resolving upon discontinuation of the drug. Symptoms can appear within the first 24 to 48 hours. Children should only use this medication under adult supervision.

• Neuroleptic Malignant Syndrome (NMS): This rare but serious condition can be life-threatening. Symptoms include high fever, muscle stiffness, and confusion. Individuals taking antipsychotics or lithium may have increased risk. Seek immediate medical help if symptoms arise.

• Masking Serious Conditions: Prochlorperazine can alleviate symptoms like nausea, potentially obscuring more severe health issues such as poisoning or overdose. It may also cause drowsiness and confusion, which can mimic other serious conditions. Children and teens with potential Reye's syndrome should avoid this medication.

• Increased Infection Risk: This drug can lower white blood cell counts, heightening infection risk. Regular blood tests may be necessary. Report symptoms like fever or sore throat to your healthcare provider promptly.

• Risk of Falls: Low blood pressure caused by prochlorperazine may result in fainting. Rise slowly from sitting or lying positions and consult your provider if dizziness persists.

• Liver Concerns: Serious liver problems may occur. Look for symptoms such as jaundice, dark urine, or clay-colored stools and contact your healthcare provider if they appear.

• Seizure Risk: If you have a history of seizures, discuss with your healthcare provider as dosage adjustments may be needed. Avoid potentially dangerous activities where sudden loss of consciousness could be harmful.

• High Prolactin Levels: Elevated prolactin can lead to symptoms like milk secretion or irregular menstrual cycles. Discuss any concerns with your healthcare provider.

• Temperature Regulation Issues: Prochlorperazine can affect body temperature control, particularly in hot environments.

Contraindications: Do not use prochlorperazine if you are in a coma, consume large amounts of alcohol, take high doses of sedative medications, are undergoing surgery (children), or are under 2 years old or weigh less than 20 pounds. Always consult your healthcare provider to ensure safe use of this medication.

Common side effects:

• drowsiness
• dizziness
• blurred vision

• dry mouth

  Less common but important to monitor:

• persistent nausea or vomiting
• mental or mood changes
• agitation or restlessness
• unusual or uncontrolled muscle movements
• shaking
• difficulty urinating
• changes in menstrual periods
• breast-related changes
• tenderness or unexpected milk production

• signs of infection such as persistent sore throat or fever

  Serious side effects:

• seizures
• neuroleptic malignant syndrome (NMS)
• high fever
• muscle stiffness
• confusion
• irregular heartbeat
• allergic reaction
• rash
• severe dizziness
• difficulty breathing
• symptoms of liver issues
• low white blood cell count
• increased susceptibility to infections

Interactions with high risk of serious adverse effects and should be avoided:

• Alfuzosin
• Amiodarone
• Amisulpride
• Arsenic Trioxide
• Astemizole
• Atazanavir
• Bedaquiline
• Bepridil
• Cisapride
• Citalopram
• Clarithromycin
• Dofetilide
• Dronedarone
• Escitalopram
• Fingolimod
• Flecainide
• Halofantrine
• Hydroquinidine
• Ibutilide
• Levomethadyl
• Mesoridazine
• Methadone
• Metoclopramide
• Moxifloxacin
• Nelfinavir
• Nilotinib
• Ondansetron
• Pimozide
• Procainamide
• Quinidine
• Quinine
• Ranolazine
• Ribociclib
• Saquinavir
• Sotalol
• Sparfloxacin
• Thioridazine
• Toloxatone
• Toremifene
• Tranylcypromine
• Vandetanib
• Vemurafenib
• Ziprasidone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Cabergoline
• Codeine
• Hydrocodone
• Alcohol
• Cannabis
• Alprazolam
• Lorazepam
• Zolpidem
• Carisoprodol
• Cyclobenzaprine
• Cetirizine
• Diphenhydramine