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Oxazepam is a medication that carries several important safety considerations. It is crucial to be aware of the potential risks and necessary precautions when using this drug. Below are key safety warnings and guidelines to ensure safe usage:

• Risk of Abuse and Addiction: Oxazepam can be habit-forming, leading to misuse, dependence, or addiction. Misuse may result in overdose and even death. Your healthcare provider will prescribe the lowest effective dose for the shortest duration necessary to minimize these risks.

• Serious Side Effects with Opioids: Combining oxazepam with opioid pain medications (e.g., codeine, hydrocodone) can severely depress the central nervous system, causing extreme sleepiness, slowed breathing, coma, or death. It is essential to avoid this combination unless under strict medical supervision. Seek emergency assistance if you experience breathing difficulties after taking oxazepam.

• Withdrawal Symptoms: Abrupt discontinuation of oxazepam can lead to serious withdrawal symptoms, which can sometimes be life-threatening. Symptoms include headaches, trouble sleeping, restlessness, hallucinations, confusion, depression, nausea, or seizures. Your doctor may gradually reduce the dose to prevent withdrawal.

• Use During Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, inform your healthcare provider. Oxazepam can slightly increase the risk of birth defects and cause withdrawal symptoms in newborns. It can also pass into breast milk, potentially affecting the baby. Discuss the risks and benefits with your doctor.

• Contraindications: Oxazepam should not be used during episodes of psychosis. Ensure to discuss any mental health concerns with your healthcare provider before starting this medication.

• Interactions with Alcohol and Other Substances: Avoid consuming alcohol and other drugs that may cause drowsiness or breathing problems while taking oxazepam, as these can amplify side effects and lead to severe complications.

• Emergency Actions: In the event of an overdose or severe side effects such as slow or shallow breathing, unusual lightheadedness, or difficulty waking up, seek immediate medical attention. Educate those around you on recognizing these symptoms to facilitate prompt action.

By adhering to these guidelines and maintaining open communication with your healthcare provider, the risks associated with oxazepam use can be effectively managed.

Common side effects:

• Drowsiness
• Dizziness
• Sensation of vertigo
• Blurred vision
• Headaches

Less common but important to monitor:

• Skin rash
• Nausea
• Swelling
• Slurred speech
• Tremors
• Restlessness
• Changes in sex drive
• Lack of energy

Serious side effects:

• Significant mental or mood changes
• Trouble speaking or walking
• Clumsiness
• Sleep disturbances
• Fainting
• Unusual tiredness
• Persistent nausea or vomiting
• Loss of appetite
• Abdominal pain
• Yellowing of the eyes or skin
• Dark urine
• Rash
• Itching or swelling of the face, tongue, or throat
• Severe dizziness
• Difficulty breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Flumazenil

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Alfentanil
• Alprazolam
• Amobarbital
• Benzhydrocodone
• Buprenorphine
• Butabarbital
• Butalbital
• Butorphanol
• Calcium Oxybate
• Cannabidiol
• Carbinoxamine
• Carisoprodol
• Cetirizine
• Chloral Hydrate
• Chlorzoxazone
• Clobazam
• Codeine
• Dantrolene
• Dihydrocodeine
• Doxylamine
• Esketamine
• Ethchlorvynol
• Fentanyl
• Flibanserin
• Fospropofol
• Gabapentin
• GabapentinEnacarbil
• Hydrocodone
• Hydromorphone
• Ketamine
• Lemborexant
• Levocetirizine
• Levorphanol
• Lofexidine
• Loxapine
• Magnesium Oxybate
• Meclizine
• Meperidine
• Mephenesin
• Mephobarbital
• Meprobamate
• Metaxalone
• Methadone
• Methocarbamol
• Methohexital
• Metoclopramide
• Midazolam
• Mirtazapine
• Morphine
• MorphineSulfate Liposome
• Nalbuphine
• Oxycodone
• Oxymorphone
• Pentazocine
• Pentobarbital
• Periciazine
• Phenobarbital
• Potassium Oxybate
• Pregabalin
• Primidone
• Propofol
• Remimazolam
• Scopolamine
• Secobarbital
• Sodium Oxybate
• Sufentanil
• Tapentadol
• Thiopental
• Tramadol
• Trazodone
• Zolpidem

Interactions with low risk that usually do not require a change in therapy:

• Rifapentine
• St John's Wort
• Theophylline