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This medication is accompanied by essential safety warnings that highlight its potential risks. Please read them thoroughly and discuss any concerns with your healthcare provider.

• Serotonin Syndrome Risk: Capmist DM contains dextromethorphan, which can increase the risk of serotonin syndrome—a rare but potentially life-threatening condition. This risk is heightened if you are also using medications that affect serotonin levels, such as certain antidepressants, MAOIs, or specific migraine treatments. Avoid using Capmist DM if you have taken monoamine oxidase inhibitors (MAOIs) in the past 14 days, or if you are currently taking drugs that elevate serotonin in the brain.

• Accidental Overdose: Capmist DM combines a cough suppressant (dextromethorphan), an expectorant (guaifenesin), and a decongestant (pseudoephedrine), which are also present in many other over-the-counter products. Using more than one product containing these ingredients can result in an accidental overdose, potentially causing severe side effects such as high blood pressure, rapid heart rate, seizures, or hallucinations. If you're uncertain whether a product contains these ingredients, consult your pharmacist.

• Exacerbation of Medical Conditions: Avoid taking Capmist DM if you have any associated risk factors unless your healthcare provider has deemed it safe. The medication can aggravate existing conditions and lead to significant side effects. Ensure your healthcare team is informed of all current or past medical conditions before starting Capmist DM. Risks include:

  • Cough due to smoking, asthma, or emphysema
  • Mucus-producing cough
  • Heart disease or high blood pressure
  • Endocrine disorders like thyroid disease or diabetes
  • Urinary issues

• Contraindications: Capmist DM should not be used if you are currently taking, or have taken, a monoamine oxidase inhibitor (MAOI) within the past two weeks. Doing so may pose serious health risks. Always consult with your healthcare provider if any of these conditions apply to you before starting this medication.

When taking this medication, some individuals may experience mild side effects such as dizziness, headache, nausea, nervousness, or trouble sleeping. These are generally not serious and often resolve on their own. However, if these symptoms persist or worsen, it is advisable to consult a healthcare provider for guidance and reassurance.

In some cases, more concerning side effects may occur. These include mental or mood changes, such as confusion or hallucinations, shaking or tremors, and weakness. Additionally, changes in heart rate or rhythm, whether fast, slow, or irregular, should be monitored closely. If you experience any of these symptoms, it is important to seek medical advice promptly to ensure your safety and well-being.

Rarely, severe side effects such as serotonin syndrome can occur, characterized by a fast heart rate, sweating, muscle stiffness or spasms, high fever, and confusion. These symptoms require immediate medical attention. Additionally, although a very serious allergic reaction to this medication is uncommon, seek urgent medical help if you notice a rash, itching, swelling, severe dizziness, or trouble breathing. Your health and safety are paramount, so do not hesitate to reach out to a healthcare professional if you have concerns about your symptoms.

While using this medication, it's crucial to avoid certain MAO inhibitors due to the risk of a severe, potentially fatal drug interaction. Do not take isocarboxazid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, or Tranylcypromine alongside this medication. Additionally, most MAO inhibitors should be avoided for at least two weeks before beginning treatment with this drug. Consult your doctor about when it is safe to start or stop using this medication.

Another drug that may interact with this medication is rolapitant.

Be aware that the ingredients in this medication are found in various prescription and nonprescription products. To prevent accidental overdose, check all your medication labels to ensure you aren't taking multiple products containing the same ingredients. If you have any doubts, speak with your pharmacist to confirm the ingredients in your medications.

This medication might affect certain medical or laboratory tests, such as urine 5-HIAA/VMA levels or brain scans for Parkinson's disease, potentially leading to inaccurate results. Inform lab technicians and all your healthcare providers that you are using this medication.