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When taking this medication, you might experience mild side effects such as drowsiness, dizziness, flushing, headache, nausea, nervousness, blurred vision, or a dry mouth, nose, or throat. These are common and usually not a cause for concern. If they persist or worsen, consider discussing them with your healthcare provider. To minimize dizziness, rise slowly from sitting or lying down. Staying hydrated can help alleviate dry mouth, and options like sugarless candy or gum might provide relief.

Serious side effects are less common but require prompt attention. These include mental or mood changes like confusion or hallucinations, shaking, difficulty urinating, and unusual weakness. If you experience any of these, contact your healthcare provider immediately. Seek urgent medical help if you notice very serious symptoms such as an irregular heartbeat or a seizure.

Though rare, severe allergic reactions can occur. Be vigilant for signs like a rash, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing, and seek immediate medical attention if they occur. Always inform your healthcare provider about any other side effects you may notice.

Some items that can interact with this medication include skin-applied antihistamines like diphenhydramine creams, ointments, and sprays. Combining this drug with MAO inhibitors can lead to a serious and possibly life-threatening interaction. Avoid using MAO inhibitors such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine while on this medication. Most MAO inhibitors should not be taken for two weeks before starting this medication. Consult your doctor for guidance on when to start or stop this treatment.

This medication's ingredients are often found in other prescription and over-the-counter products. Carefully read all medication labels to ensure you're not using multiple products with the same ingredient(s). If you're uncertain, speak with your pharmacist.

Inform your doctor or pharmacist if you are using other products that may cause drowsiness. These include opioid pain relievers or cough suppressants (like codeine or hydrocodone), alcohol, cannabis, sleep or anxiety medications (such as Alprazolam, Lorazepam, or Zolpidem), muscle relaxants (like Carisoprodol or Cyclobenzaprine), and other antihistamines (such as Cetirizine or diphenhydramine).

Check labels on all your medications, including allergy or cold remedies, as they may also cause drowsiness. Consult your pharmacist to ensure safe use of these products.

This medication might interfere with certain laboratory tests, such as allergy skin tests, potentially leading to incorrect results. Make sure all lab personnel and your healthcare providers are aware that you are using this medication.